Not the Best Staining from cFOS

Vascular Dysfunction
University of Heidelberg
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

Synaptic systems

Product Name:

cFOS antibody

Catalog Number:

226004

Clone Number:

N/A

Actively firing neurons were stained with cFOS staining. however the staining was not efficient and most of the dapi positive cells were labeled with cFOS antibody in the whole cortex.

Experimental Design and Results Summary

Applications

Immunofluorescence

Sample

Postnatal mouse brain tissue-P12, cryosections

Primary Incubation

1:300, 4° C overnight

Blocking Agent

10% NDS in PBST (0.5% TritonX 100)

Secondary Incubation

1:500, AF 488

Tertiary Incubation

none

Detection

Immunofluorescence

Results Summary

not efficient labelling,

DOI or PMID #

N/A

Additional Notes

Works better with Antigen retrieval (10mM Sodium citrate-boiling)

Related Categories

Image Gallery

Summary

The Good

Labelling could be good if standardized

The Bad

High background, needs to be used with another efficient cFOS antibody

The Bottom Line

Not recommended, requires a lot of standardization

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