CD45.2 Antibody Gives Good Results

Oncology
Johns Hopkins School of Medicine
Graduate Student

Overall

Quality of Results

Ease-of-Optimization

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Company:

BD Biosciences

Product Name:

BUV395 Mouse Anti-Mouse CD45.2

Catalog Number:

564616

Clone Number:

104

CD45.2 is routinely used a congenic marker in mouse immunology as it is found all on all hematopoietic cells. We use this marker to identify donor T cells in our experiments when we perform adoptive transfer experiments.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Murine tumor samples

Primary Incubation

1:500 in FACS Buffer (2% FBS/PBS)

Blocking Agent

FC Block in FACS buffer

Secondary Incubation

N/A

Tertiary Incubation

N/A

Detection

Cytek Aurora (4 Laser (BVR, UV)

Results Summary

We can easily identify our donor T cells based on CD45.2 and CD45.1 expression in our tumor samples.

DOI or PMID #

N/A

Additional Notes

Titrate depending on cells since it can be too bright

Related Categories

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Summary

The Good

Nice robust antibody that is readily available in UV from BD.

The Bad

None

The Bottom Line

Recommend this antibody to use on the UV laser to detect CD45.2 expression.

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