Donkey Serum for Immunofluorescence Gives Good Results

Centre for Cellular & Molecular Biology
Project JRF
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

Sigma-Aldrich

Product Name:

Donkey serum

Catalog Number:

D9663

Info: Supplier Page 

Blocking binding of the antibody to unspecific proteins is an important step in immunocytochemistry which can achieved by using protein bovine serum albumin or skimmed milk. While performing immunofluorescence in cultured cells, sigma donkey serum serves as a very good blocker of non-specific reactions. 10% donkey serum in 0.2% TritonX-100 in PBS is a composition of blocking solution that works well for cultured cells when incubated for 2 hours at room temperature.

Experimental Design and Results Summary

Application

Immunocytochemistry, Immunofluorescence

Starting Material

Fixed cultured cells

Tips

Aliquote from the main stock to smaller volumes and to avoid freeze-thawing which creates precipitates in the serum.

Results Summary

No nonspecific reactions, that give a crisp fluorescence signals upon imaging.

DOI or PMID #

N/A

Related Categories

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Summary

The Good

Results are very consisitent, easy to work and maintain.

The Bad

Nothing bad or difficult for the users

The Bottom Line

My full recommendation for this donkey serum in your immunofluorescence experiment.

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