Great p27 Antibody

Medicine
Harvard Medical School
Post-doctoral fellow

Overall

Quality of Results

Ease-of-Optimization

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Company:

Cell Signaling Technologies

Product Name:

p27 Kip1 antibody

Catalog Number:

3686S

Clone Number:

D69C12

I used this antibody to determine check the efficiency of p27 knockdown in 293T cells. scramble siRNA and p27 specific siRNA-transfected cells were subjected to western blot analysis.

Experimental Design and Results Summary

Applications

Western Blot

Sample

Scramble siRNA and p27 specific siRNA-transfected 293T cells

Primary Incubation

1:1000 dilution, 18 hours at 4 degrees with gentle shaking

Blocking Agent

5% non-fat dry milk in Tris buffer containing 0.1% Tween-20

Secondary Incubation

HRP-conjugated anti-rabbit antibody 1:2000 dilution, 1 hour at room temperature with gentle shaking

Tertiary Incubation

Not applicable

Detection

ECL based detection

Results Summary

p27-specific siRNA did not work efficiently at knocking down the gene as depicted by the western blot.

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

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Summary

The Good

Specificity

The Bad

Nothing

The Bottom Line

This antibody worked really well for Western blot based detection of p27 kip1 protein.

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