Pretty Good Anti-mouse IgM

B cell memory
Deutsches Rheuma-Forschungszentrum, a Leibniz Institute
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

Miltenyi Biotec

Product Name:

IgM Antibody, anti-mouse, VioBlue®, REAfinity™

Catalog Number:

130-116-215

Clone Number:

REA979

Antibodies are produced by plasma cells (PC) that are terminally differentiated B cells and play crucial roles in host protection against infections but are considered to mediate autoimmunity in patients with rheumatic diseases, such as systemic lupus (SLE) or rheumatoid arthritis (RA). Our research aims at understanding the biology of antibody-secreting cells (ASC) in health and disease. In this particular experiment, we are looking for IgM-expressing B cells.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Mouse spleen

Primary Incubation

Anti-mouse IgM VioBlue 1/25, 15', 4°C

Blocking Agent

Fc block (2.4G2 clone)

Secondary Incubation

NA

Tertiary Incubation

NA

Detection

Flow cytometer

Results Summary

We could very nicely stain IgM+CD19+ B cells.

DOI or PMID #

N/A

Additional Notes

VioBlue can be read in the same channel than BV421.

Image Gallery

Summary

The Good

It works well

The Bad

NA

The Bottom Line

It can be used

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