Tryspin for Tissue Dissociation

Centre for Cellular & Molecular Biology
Project JRF
Postdoctoral Researcher

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Company:

Sigma

Product Name:

Trypsin Solution from Porcine Pancreas

Catalog Number:

T4549

This trypsin solution from Sigma is a 10 times concentrate. I use this trypsin (1X final concentration) for the dissociation of brain telencephalon to obtain cells from cortex and ventricular zone. The trypsin does efficient tissue dissociation however, not harsh for the cells when incubated for not more than 20mins.

Experimental Design and Results Summary

Application

For establishing primary culture and for the dissociation of cultured cells.

Starting Material

Brain tissues or cultured cells.

Tips

Use 1X final concentration for tissue dissociation.

Results Summary

Dissociated single cells from tissues and cultured cells.

Image Gallery

Summary

The Good

Not too harsh for cells when incubated for less than 20 min.

The Bad

Nothing much, but try to optimise the concentration for your cultured cells.

The Bottom Line

Highly recommended for primary neuronal cultures from hippocampus and cortex.

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