Good Way to Stain pSyk

B cell memory
Deutsches Rheuma-Forschungszentrum, a Leibniz Institute
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

What do these ratings mean?
Write a Review

Company:

BD Biosciences

Product Name:

PE Mouse Anti-Zap70 (Y319)/Syk (Y352)

Catalog Number:

557881

Clone Number:

17A/P-ZAP70

Browse Similar Products: Syk Flow Cytometry Antibodies

Antibodies are produced by plasma cells (PC) that are terminally differentiated B cells and play crucial roles in host protection against infections but are considered to mediate autoimmunity in patients with rheumatic diseases, such as systemic lupus (SLE) or rheumatoid arthritis (RA). Our research aims at understanding the biology of B cells and antibody secreting cells (ASC) in health and disease. In this experiment, we stained phopho-Syk before and after BCR stimulation.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Isolated PBMCs from HD peripheral blood

Primary Incubation

Lyse/Fix buffer (BD Biosciences) 10' 37◦C

Blocking Agent

Fc Block

Secondary Incubation

Anti-pSyk PE 1/10

Tertiary Incubation

N/A

Detection

Flow cytometer

Results Summary

B cells upregulate p-Syk upon BCR stimulation.

DOI or PMID #

31616406

Additional Notes

N/A

Related Categories

Image Gallery

Summary

The Good

It works.

The Bad

Could be cheaper.

The Bottom Line

Good option to stain p-Syk

Share your experience with other scientists. Write a Review! »

Join the discussion