Nice Flow Antibody to Identify TNFa Secretion Via Flow Cytometry

Oncology
Johns Hopkins School of Medicine
Postdoctoral Fellow

Overall

Quality of Results

Ease-of-Optimization

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Company:

BD Biosciences

Product Name:

PE Rat Anti-Mouse TNF

Catalog Number:

554419

Clone Number:

MP6-XT22

Browse Similar Products: TNF Flow Cytometry Antibodies

Our T cell lab assesses T cell function based on cytokine expression such as IFNg, Granzyme B, IL-2 and TNFa (alpha). These cytokines can be detected using intracellular staining upon stimulation with flow cytometry. We use this antibody to detect intracellular expression of TNFa in activated T cells.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Activated murine CD8+ T cells

Primary Incubation

1:500 in 1x BD Permwash buffer (intracellular staining) for 1 hr at RT

Blocking Agent

FC Block (CD16.32) in FACS solution during surface staining

Secondary Incubation

N/A

Tertiary Incubation

N/A

Detection

Flow cytometer (Celesta)

Results Summary

We readily detect nice intracellular TNFa expression in CD8+ T cells. These cells also expressed IFNg as well.

DOI or PMID #

N/A

Additional Notes

Titrate appropriately since depends on experimental conditions.

Image Gallery

Summary

The Good

Reliable and good distinct staining.

The Bad

None

The Bottom Line

Great flow antibody to identify TNFa expressing T cells especially in bright PE channel.

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