This BioLegend L1CAM Antibody Works Great!

LIBST/FYMO
UCLouvain
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

BioLegend

Product Name:

Alexa Fluor® 647 anti-human CD171 (L1CAM) Antibody

Catalog Number:

371607

Clone Number:

L1-OV198.5

We tested this antibody in FACS and in IF to detect human L1CAM. It works great in both applications, very sensitive and specific (signal disappears when L1CAM is depleted with siRNAs). However, it didn't work in WB.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

HeLa cells

Primary Incubation

1:100 for 30 min at RT

Blocking Agent

BSA 0.2%

Secondary Incubation

None (primary already coupled to fluorophore)

Tertiary Incubation

None (primary already coupled to fluorophore)

Detection

Fluorescence

Results Summary

Very specific detection of L1CAM, see the image for FACS result (blue curve: unlabelled cells; red curve: control siRNA treated cells; green curve: L1CAM siRNA treated cells). Upon L1CAM depletion, only 4% of signal is remaining.

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

Image Gallery

Summary

The Good

Sensitive and specific

The Bad

Nothing

The Bottom Line

Great to detect L1CAM at cell surface in FACS!

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