CD45 Antibody (for Flow Cytometry) from Becton Dickinson

Division of BioMedical Sciences, Faculty of Medicine
Memorial University of Newfoundland
Research Assistant

Overall

Quality of Results

Ease-of-Optimization

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Company:

BD Biosciences

Product Name:

APC Mouse Anti-Human CD45

Catalog Number:

555485

Clone Number:

HI30

Browse Similar Products: CD45 Flow Cytometry Antibodies

This antibody was used in a set of experiments that were performed to determine the relative proportion of T cell subsets using whole blood samples. This antibody was used to distinguish leukocytes from erythrocytes, platelets, and other circulating non-leukocyte cells in whole blood. This antibody easily resolved the various leukocyte populations from the other constituents in whole blood and allowed clear identification of T cell subsets when multiplexed with other antibodies.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Whole blood from a healthy adult donor (collected in a vacutainer tube containing EDTA)

Primary Incubation

5ul of CD45 antibody (BD 555485) incubated for 10min at room temperature with approximately 100ul of whole blood

Blocking Agent

N/A

Secondary Incubation

N/A

Tertiary Incubation

N/A

Detection

CytoFLEX (Beckman Coulter), software FlowJo v10

Results Summary

This antibody worked very well in flow cytometry to identify CD45+ leukocytes. When plotted against SSC, granulocyte, monocyte, and lymphocyte populations could be easily resolved from other cells in whole blood.

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

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Summary

The Good

Very specific, minimal background, easy to use to stain whole blood without purifying cells

The Bad

None

The Bottom Line

This is a very good antibody to detect CD45 on the surface of white blood cells when using whole blood as your sample.

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