New England Biolabs
Q5 site-directed mutagenesis kit
E0552S
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I use this kit to do quikchange to introduce all kinds of mutation, deletion and insertion to the DNA of interest. It is very convenient and usually works well.
Cloning
N/A
Design the primer using NEB website
The cloning procedure is much easier and success rate of cloning is pretty high
Convenient and fast
None
This system is very powerful for those who do a lot of cloning to generate mutations. Price is also reasonable.