Tocris Bioscience
10-DEBC hydrochloride
2558
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As part of our current study, we investigated the role of AKT pathway on the LPA induced inflammatory phenotype in microglia (downstream signaling). BV2 cells were incubated for different time points with LPA (1µM) in the presence or absence of AKT X (5µM).
WB
BV2 microglia cells
Nothing specific
AKT inhibition totally decreased the expression of 2 pro-inflammatory transcription factors (pSTAT1 and pp65). The inhibitor was diluted in water.
N/A
Easy to use, reproducible results
None
Highly potent Akt inhibitor.