Abcam
C59, Wnt antagonist
ab142216
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C59 functions to inhibit secretion of Wnt ligand from cells. We investigated the effects of this inhibitor on growth of human breast cancer cells, as these cells are dependent on Wnt ligand secretion.
Cytotoxicity Experiments
Human breast cancer cells
Make sure to use a wide range to determine optimal concentration for effects
C59 was found to inhibit growth of human breast cancer cell lines such as MB-231 and MCF-7.
N/A
Effective inhibitor
C59 can be dissolved in DMSO for treatment of human breast cancer cells to determine dependency on Wnt signaling. This can also be a viable option as a positive control for comparison with other agents.