D609 Does Not Inhibit LPA-Induced COX-2 Expression

Medical University of Graz
Division of Cardiology
Postdoctoral Researcher

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Company:

Tocris Bioscience

Product Name:

D609

Catalog Number:

1437/10

Human osteosarcoma cells were incubated with 20 μM D609 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. D609 was ineffective against LPA-induced COX-2 expression while other inhibitors showed inhibition.

Experimental Design and Results Summary

Application

Cell culture

Starting Material

Human osteosarcoma cells

Tips

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Results Summary

Human osteosarcoma cells were incubated with 20 μM D609 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis.

DOI or PMID #

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Summary

The Good

Works as expected

The Bad

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The Bottom Line

D609 was ineffective against LPA-induced COX-2 expression in human osteosarcoma cells.

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