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Alexa Fluor 647 anti-mouse CD98 (4F2) Antibody
128210
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Our lab studies the role of mTOR signaling in CD8 T cell differentiation and function. mTOR signaling controls the metabolic programming of T cells. Programming of T cells also involves dynamic changes in surface expression of critical solute carriers such as the leucine transporter. Therefore, we use CD98 as a surrogate marker for this transporter since it's part of the heterodimer of the transporter.
Flow Cytometry
Murine T cells
1:1000 in 2% FBS/PBS solution (FACS)
FC Block 100ng/mL in FACS solution
N/A
Flow Cytometer Celesta
We are easily able to determine surface expression of CD98 on T cells. More so, we are able to get great separation of this critical transporter between two population of CD8 T cells.
27064374
Titrate depending on cells since it can be too bright
Great robust antibody. Also able to use it for IF applications due to AF647 conjugate for photostability.
None whatsoever
Highly recommend this antibody to detect CD98 expression. Very reliable and consistent.