Betaine Solution to Improve PCR Results

Harvard Medical School
Cell Biology
Postdoctoral Fellow

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Company:

MilliporeSigma

Product Name:

Betaine solution

Catalog Number:

B0300

I always use betaine in my PCR reaction for genotyping which greatly helps to get rid of non-specific bands. I had many cases where adding betaine makes a huge difference in the PCR result.

Experimental Design and Results Summary

Application

PCR for genotyping

Starting Material

N/A

Tips

Use 10% betaine in the reaction mix

Results Summary

By adding betaine in the PCR reaction, my genotyping PCR is much more specific and generates very neat results compared to without betaine addition

DOI or PMID #

N/A

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Summary

The Good

Greatly improve results

The Bad

None

The Bottom Line

I highly recommend trying betaine in your PCR reaction if you have a problem with getting a specific band.

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