Best FLAG Antibody

Cell Biology
Harvard Medical School
Postdoctoral Fellow

Overall

Quality of Results

Ease-of-Optimization

What do these ratings mean?
Write a Review

Company:

Sigma

Product Name:

Monoclonal ANTI-FLAG® M2 antibody produced in mouse

Catalog Number:

F1804-200UG

Clone Number:

Browse Similar Products: M2 Western Blot Antibodies

My research focuses on studying posttranslational modification of proteins. I use expressed protein ligation technique to study the effect of phosphorylation and ubiquitination on tumor suppressor protein PTEN and its related NEDD4 HECT E3 ligases. I am also studying the dynamics of ubiquitin-proteasome system using mass spectrometry based proteomics. This monoclonal anti-FLAG M2 antibody is very sensitive and specific for FLAG peptide. We used for western, flow cytometry, and immunostaining microscopy.

Experimental Design and Results Summary

Applications

Western Blot

Sample

Cell lysate

Primary Incubation

1:2000, 4℃, overnight

Blocking Agent

5% milk

Secondary Incubation

1:5000, room temperature, 1 hour

Tertiary Incubation

None

Detection

ECL

Results Summary

By using this antibody, we can always detect strong bands at the correct size for the proteins tagged with FLAG peptide. As shown in the figure, there was no signal detected in the lane without DOX induction, but after DOX induction, you can detect increased expression of the FLAG-tagged protein, which indicates that this antibody is very specific.

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

Image Gallery

Summary

The Good

High sensitivity and specificity

The Bad

None

The Bottom Line

This is a very reliable FLAG antibody with high sensitivity and specificity for experiments including western blot, immunofluorescence microscopy, and flow cytometry.

Share your experience with other scientists. Write a Review! »

Join the discussion