Tocris Bioscience
Go 6983
2285/1
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LPA treatment induced PKC activity in osteosarcoma cells. Therefore, we used Go 6983 to investigate its role in COX-2 activation.
Cell culture
Human osteosarcoma cells
Human osteosarcoma cells were incubated with 20 μM Go 6983 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis.
N/A
Go 6983 abolished LPA-induced COX-2 expression.
Worked as expected
Go 6983 can be used to investigate PKC signaling.