Great ECL HRP Substrate

Johns Hopkins School of Medicine
Oncology
Postdoctoral Fellow

Overall

Quality of Results

Ease-of-Optimization

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Company:

Thermo Scientific

Product Name:

SuperSignal™ West Pico PLUS Chemiluminescent Substrate

Catalog Number:

34578

As an immunology lab, we perform many western blots for protein and signaling analysis. Using primary and HRP secondary antibodies for blotting, we use the ECL Pico substrate for the our Chemiluminescent substrate.

Experimental Design and Results Summary

Application

Western Blotting Analysis

Starting Material

T lymphocytes

Protocol Overview

Perform routine primary and secondary HRP antibody incubation along with appropriate washes in between. After washing the secondary away, mix 1:1 volume of the peroxide solution (Clear bottle) with the enhancer (Brown bottle). Add the mixed solution onto the membrane for 5 minutes and move around to ensure maximum coverage before acquisition.

Tips

Mix 1:1 well.

Results Summary

Signal strength is very durable over time and robust.

DOI or PMID #

N/A

Additional Notes

Can be kept at room temp which makes it great!

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Summary

The Good

Easy to use and relatively cheap if bigger bottle bought.

The Bad

None what so ever!

The Bottom Line

Great ECL substrate for most routine abundant proteins. Never have issues capturing targets.

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