Mouse Inflammatory Cytokines Multi-Analyte ELISA Assay

Thomas Jefferson University
Neuroscience
Postdoctoral Fellow

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Company:

Qiagen

Product Name:

Mouse Inflammatory Cytokines Multi-Analyte ELISArray™ Kits

Catalog Number:

Qiagen, MEM‐004A

We measured common pro‐inflammatory cytokine levels in the WTFUS and mutFUS ACM by ELISA. Among those, we identified TNFα as the most highly altered secreted factor in mutFUS ACM (3.8‐fold increase over WTFUS ACM). Further, we validated this result using a second ELISA containing a new set of sandwich antibodies, and found mutFUS ACM contains significantly more TNFα compared to WTFUS or Non‐transduced (NT) ACM. This kit works great and saves time.

Experimental Design and Results Summary

Application

ELISA

Starting Material

Conditioned media of mouse astrocytes

Protocol Overview

For inflammatory array, Mouse Inflammatory Cytokines Multi‐Analyte ELISArray was run per manufacturer instructions (Qiagen, MEM‐004A).

Tips

Incubation time needs to be optimized

Results Summary

TNFα is the most highly altered secreted factor in mutFUS ACM (3.8‐fold increase over WTFUS ACM)

DOI or PMID #

N/A

Additional Notes

N/A

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Summary

The Good

Saves time

The Bad

None

The Bottom Line

Highly sensitive multi-analyte ELISA kit

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