Good Depletion Kit

National Institute of Health
National Cancer Institute
Postdoctoral Fellow

Overall

Quality of Results

Ease-of-Optimization

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Company:

Biolegend

Product Name:

MojoSort™ Mouse CD45 Nanobeads

Catalog Number:

480028

The general aim is to explore some rare cells in bone marrow that are CD45-. CD45 depletion was performed to remove most cells unwanted. The reason this product was selected was because it was half the price compared with competitors and of good quality.

Experimental Design and Results Summary

Application

Depletion of CD45+ cells from whole mouse bone marrow

Starting Material

Freshly isolated mouse bone marrow

Protocol Overview

Followed the protocol of Biolegend.

Tips

You can perform twice with half the amount recommended each time and get a better result.

Results Summary

Up to 95% CD45+ cells were removed. I have repeated several times and the results are constant. As you can tell from the figure, CD45- cells % increased from 3.36% to 55.9%, namely, 15 out of 16 CD45+ cells were removed, ~95%.

DOI or PMID #

N/A

Additional Notes

N/A

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Summary

The Good

FAST and efficient.

The Bad

You need a strong magnet that can perform bulk depletion.

The Bottom Line

Basically, I strongly recommend this product.

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