Average Antibody For PCNA Detection

Department of Microbiology and Immunology
University of Illinois, Chicago
PostDoctoral Research Fellow

Overall

Quality of Results

Ease-of-Optimization

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Company:

Abcam

Product Name:

Anti-PCNA antibody

Catalog Number:

ab18197

PCNA is a nuclear antigen that represents cellular proliferation. It is often used as a nuclear marker for Western blotting experiments especially those related to the cell cycle. We used 293T nuclear lysate to probe PCNA as a nuclear marker for loading control in western blotting.

Experimental Design and Results Summary

Applications

Western Blot

Sample

Nuclear extracts of 293T

Primary Incubation

1:2000 dilution prepared in blocking solution, incubated overnight at 4 degrees

Blocking Agent

5% skimmed non-fat milk in PBST20

Secondary Incubation

1:5000 anti-rabbit HRP antibody, incubated for an hour at RT

Tertiary Incubation

None

Detection

ECL based detection was used

Results Summary

This antibody gave few non -specific bands along with the right band at approximately 30 kDa.

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

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Summary

The Good

Good antibody

The Bad

It gives a few non specific bands.

The Bottom Line

In total, it is a decent antibody.

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