Anti-Mouse Granzyme B

Medical Oncology
DFCI
Postdoc

Overall

Quality of Results

Ease-of-Optimization

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Company:

Invitrogen Antibodies

Product Name:

Granzyme B Monoclonal Antibody

Catalog Number:

25-8898-82

My research aim is to investigate the response of the immune system after immune-therapy. This antibody is a good GranzymeB marker, that has been tested on lymphocytes extracted from spleen, lymph nodes and glioma tumor-bearing mice with the aim to evaluate activation in CD4 and CD8 T cells.

Experimental Design and Results Summary

Applications

Flow Cytometry

Sample

Mouse Splenocytes, TILs

Primary Incubation

30min

Blocking Agent

Fc

Secondary Incubation

N/A

Tertiary Incubation

N/A

Detection

Fortessa

Results Summary

After cell extraction and blocking with Fc Block, wash your sample 2x with washing buffer, stain for 30min RT with your extracellular staining, wash 2x and then proceed with intracellular staining protocol for GranzymeB (1:200).TILs extract from brain-tumor mice and spleenocytes were gated for Live/CD45+/CD3+/CD8+ and Live/CD45+/CD3+/CD4+

DOI or PMID #

N/A

Additional Notes

N/A

Related Categories

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Summary

The Good

High positive population

The Bad

Price

The Bottom Line

PE-Cy7 anti-mouse GranzymeB has been chosen because is a bright antibody with a good MFI and fit in my multicolor panel designed for T cell analysis.

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