Revvity
RediJect Coelenterazine h Bioluminescent Substrate
760506
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Our lab uses HIV molecular clones that express Renilla luciferase reporter. We have developed different mouse models that support HIV infection, and test different therapeutics and vaccines in our models. Using this in vivo imaging kit, we can detect HIV infection in vivo, and visualize any protective role that our treatments are providing.
In vivo imaging
HIV infected mice
Very simple to use. You just inject the Coelenterazine h right before imaging, and image the mice immediately. It gets cleared from their system within 30 min, so you could image again later.
Make sure to image animals before injecting the substrate, so that you remove any background bioluminescence.
You can get great images that visualize where the infection is predominantly located in the animal.
N/A
Work very nicely
None
Very cool assay. Definitely recommend if you use a reporter for infections, cancer cells etc. These images are very powerful.