Ark Pharm, Inc.
Brevianamide F
AK169895
Different cyclic-di-peptides were used to test if it could affect the expression of cereblon in HCT116 cells. The HCT116 cells were treated with Brevianamide F at a final concentration of 0, 1, 3, 10 uM overnight. The expression of cereblon was detected by Western blotting.
Western blotting
HCT116
The expresson of cereblon was examined by Western blotting in Brevianamide F exposed HCT116 cells.
Brevianamide F was dissolved in DMSO
No differential change of cereblon expression was dectected in Brevianamide F treated HCT116 cells.
N/A
It works as expected
The drug works as expected