Chem-Impex International
CYCLO(-GLY-TRP)
11050
Different cyclic-di-peptides were used to test if it could affect the expression of cereblon in HCT116 cells. The HCT116 cells were treated with CYCLO(-GLY-TRP) at a final concentration of 0, 1 3, 10 uM to test the cereblon expression.
Westen blotting
HCT116
The HCT116 cells were treated with different doses of cyclo-(Gly-Trp) overnight, and the expression of cereblon was detected by Western blotting.
cyclo-(Gly-Trp) was dissolved in DMSO
The expression of cereblon was increased with the input of cyclo-(Gly-Trp)
N/A
The drug works