Inexpensive 7-AAD Viability Dye

University of Rochester
MBI
Graduate Student

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Company:

Tonbo Biosciences

Product Name:

7-AAD

Catalog Number:

13-6993

Mice were injected IP with heat-killed E. coli and peritoneal lavage recovered. Immune populations were identified by flow cytometry on total peritoneal lavage. 7-AAD was added to exclude dead cells.

Experimental Design and Results Summary

Application

Flow Cytometry

Starting Material

Peritoneal cells - 8h after heat-killed E. coli injection

Protocol Overview

Cells were incubated 1:200 Ly6c-eFlour450 1:400 Ly6g-APC/Cy7 - 30 minutes on ice, blocked with 1:100 FcBlock for 5 minutes on ice, and then incubated 1:80 with 7AAD on ice. They were then imaged with LSRII Flow Cytometer.

Tips

None

Results Summary

Dead cells were easily excluded by 7AAD staining of cells with compromised cell membranes.

Additional Notes

7-AAD was left in during run

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Summary

The Good

Inexpensive, bright staining

The Bad

None

The Bottom Line

Inexpensive live/dead stain allows exclusion of dead cells from flow analysis. 500 tests is $35 at the time of writing.

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