Specific marker for macrophages

Urology
Univ of Oklahoma Health Science Center
Senior Research Assistant

Overall

Quality of Results

Ease-of-Optimization

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Company:

Abcam

Product Name:

Anti-CD68 antibody [ED1]

Catalog Number:

ab31630

Our research investigates inflammation during bladder regeneration. Macrophages are one of the inflammatory cells we study. We were trying to find a specific antibody to detect macrophages in rat tissue. CD68 is a marker for macrophages. The reason we chose this antibody is that this antibody is a monoclonal antibody used for immunohistochemistry and can be used in multiple species, including rat. Also, it produces lots of data images to ensure the quality of the antibody.

Experimental Design and Results Summary

Applications

Immunohistochemistry

Sample

Rat bladder tissue

Primary Incubation

1:800 in 1% BSA, 4C overnight

Blocking Agent

10% goat serum in 1x TBS

Secondary Incubation

1:400 at room temperature, 1 hour

Tertiary Incubation

Strep HRP 1:400 at room temp for 30 minutes

Detection

DAB 2 minutes

Results Summary

Good staining of macrophage cells.

Additional Notes

None

Related Categories

Image Gallery

Summary

The Good

Good contrast, no background, sensitive

The Bad

Not 100 % specific on macrophages

The Bottom Line

Nice IHC staining for macrophages in rat tissue without any background.

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