As the global population ages, understanding the molecular changes associated with aging has become increasingly important in preventing age-related diseases. A research team led by Masaki Takasugi and Naoko Ohtani at Osaka Metropolitan University has developed the Mouse Aging Proteomic Atlas, addressing a significant gap in aging research by mapping protein changes across various tissues.
Previous studies focused on mRNA levels to create an atlas of aging-related changes in major tissues, but a similar resource for proteins was lacking. To address this, the team analyzed the proteomes and transcriptomes of several tissues—brain, artery, heart, kidney, liver, lung, skeletal muscle, and skin—from mice aged 6 to 30 months. This analysis included extracellular matrix-enriched fractions, allowing for a detailed examination of how aging affects protein groups in these tissues.
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Dr. Takasugi noted the significance of their findings: “By clarifying the changes in various tissues due to aging in detail with regard to the number of proteins that are directly linked to gene function, we have dramatically improved our understanding of the overall changes on the molecular level.” The study revealed that certain proteins in the extracellular matrix increase with age, providing insights into the biological processes underlying aging.
Professor Ohtani added that “the results of this research are expected to contribute to a better understanding of the changes that occur with age.” The findings were published in Nature Communications, offering a valuable resource for future studies aimed at elucidating the mechanisms of aging and developing interventions for age-related conditions.