Newly Discovered Protein OSER1 Found to Influence Longevity

Researchers at the University of Copenhagen's Center for Healthy Aging have identified a protein called OSER1 as a significant factor in extending lifespan, potentially opening new avenues for treating age-related diseases.

The study, led by Lene Juel Rasmussen, found that OSER1 is present in various organisms, including fruit flies, nematodes, silkworms, and humans. This widespread presence suggests that the protein's longevity-promoting effects may be applicable across species, including humans.

Zhiquan Li, first author of the study published in Nature Communications, emphasized the importance of identifying longevity factors that exist in multiple organisms: "We screened the potential longevity proteins that exist in many organisms, including humans. Because at the end of the day we are interested in identifying human longevity genes for possible interventions and drug discoveries".

The research team discovered OSER1 while studying proteins regulated by FOXO, a known longevity regulatory hub. Out of 10 genes that affected longevity when manipulated, OSER1 showed the most significant impact.

This discovery could have far-reaching implications for understanding and potentially treating age-related diseases. The researchers hope that further study of OSER1 will provide insights into specific age-related diseases and aging processes.

"We are currently focused on uncovering the role of OSER1 in humans, but the lack of existing literature presents a challenge, as very little has been published on this topic to date," Li explained.