Gold Nanoparticle Adhesive Bandage Enables Rapid COVID-19 Testing

Researchers at NYU Abu Dhabi have developed a novel hybrid (vertical-lateral-vertical) flow assay in the form of a finger-stick point-of-care device, similar to an adhesive bandage, that utilizes gold nanoparticles to provide a rapid and affordable testing method for COVID-19. The bandage detects immune antibodies, specifically IgM and IgG, which are produced in response to SARS-CoV-2 infection. This technology serves as a valuable tool for identifying infected individuals and monitoring the spread of pandemics. The bandage can be easily applied to a pinprick fingertip and works by using nanotechnology-based gold nanoparticles with antigens attached to them. The antigens recognize and bind to the antibodies, resulting in a color change that indicates the individual's infection status within minutes.

The low-cost and disposable nature of the bandage makes it suitable for large-scale detection and screening, including at home, in public facilities, and in rural regions with limited access to testing facilities. The research team, led by Associate Professor Mohammad Qasaimeh, envisions the bandage's potential in detecting and screening other emerging viral infections in the future. They also plan to incorporate biodegradable porous microneedles into the bandage for efficient finger pricking.

The technology was described in a paper published in Microsystems and Nanoengineering. The researchers emphasize the importance of this user-friendly test in providing critical information about an individual's immune response to the SARS-CoV-2 infection. They believe that real-time screening using adhesive bandage tests, combined with smartphone readouts and dedicated mobile apps, could enable early detection and help prevent future outbreaks and pandemics.