Researchers at ETH Zurich and their colleagues at EPFL have discovered a new type of cell in mammalian fatty tissue that hinders the formation of new fat cells, which they say prevents the creation of "good" fat. More details on these adipogenesis-regulatory cells can be found in their paper published earlier this week in Nature.
It is known that fat cells arise from progenitor cells and, once differentiated, they are unlikely to keep dividing. "We were looking for these kinds of progenitor cell in the fat tissues of mice when we stumbled across a previously unknown type of fat cell with interesting properties," says Christian Wolfrum, professor for translational nutritional biology at ETH.
The researchers used single-cell transcriptomicsin a mouse model to reveal distinct subpopulations of adipose stem and precursor cells in the stromal vascular fraction of subcutaneous adipose tissue.
Experiments in mice and with human fatty tissues showed that it is a regulatory cell that appears to be constantly sending signals to the surrounding tissue. "We first identified four proteins that work together to prevent progenitor cells from turning into new fat cells," says Hua Dong, a doctoral student in Wolfrum's group and one of the lead authors of the study. The scientists dubbed the newly discovered cell type "Aregs", which stands for adipogenesis-regulatory cells.
The new cell type opens up intriguing treatment possibilities. When we gain weight, the energy-storing white adipose tissue can grow in one of two ways: in most overweight people, the existing fat cells get bigger. At some point, the cells can no longer store the fat and they release it into the bloodstream, which deposits it in the liver and muscles, thus increasing the risk of diabetes and other secondary conditions. Yet in about 20% of overweight people, the fatty tissues produce new cells. Thanks to these additional "containers", these people can better store the excess fat and remain healthy.
Thus far, obesity researchers and pharmaceutical companies have focused on how to activate progenitor cells in order to multiply the number of fat cells. "Still, no one really understood why new cells form so rarely, even in adipose tissue with lots of progenitor cells," Wolfrum says. The inhibiting Aregs now provide an explanation.
This discovery also opens up promising avenues for future therapies. For example, the researchers were able to demonstrate that new fat cells do in fact appear when the Aregs have been removed from the fatty tissue. In addition, they found indications that these fat regulators appear more frequently in obese mice with large fat cells.