Inside the Application

In Vivo Models

Crown Biosciences

Crown Bioscience
16550 West Bernardo Drive
San Diego, California 92127
USA
Ph: 858 622 2900
https://www.crownbio.com/

Headquartered in California, US, Crown Bioscience is a global contract research organization (CRO) providing discovery, preclinical and translational platforms and services to advance oncology and immuno-oncology.

We are known for our high-quality and expansive in vivo, in vitro, and ex vivo preclinical models, and partner with our clients to quantify the efficacy and pharmacological profile of their drug candidate(s) before they move into the clinic. We aim to deliver superior drug candidates to ensure that patients get the right treatment at the right time.

Our Mission

Our mission is to empower our customers to improve human health.

We do this by engaging the finest scientific talent, upholding the highest quality standards, and relentlessly pursuing innovation.
Every day we strive to accelerate and de-risk drug development to help realize a world where every patient gets the right treatment, at the right time.


Our Vision

Together we can realize a world where every patient gets the right treatment, at the right time.

Product Highlights

  • Humanized Models

    Crown Bioscience
    Crown Bioscience's humanized patient-derived xenograft (PDX) platform (HSC-PDX) combines the predictive power of HuPrime® PDX models with human hematopoietic stem cell (HSC) engraftment. HSC-PDX models provide the most human disease relevant in vivo platform for your human-specific immunotherapy evaluation.
  • Cell Line Derived Xenograft (CDX) Models

    Crown Bioscience
    As an integral step in the oncology drug discovery process, cell line derived xenograft models provide key decision-making information to allow an agent to move forward, and clients to advance their preclinical development programs in a timely and cost-effective manner. Crown Bioscience has established multiple in vivo assay systems to evaluate novel anticancer compounds, with each assay ...
  • Patient-derived Xenograft (PDX) Models

    Crown Bioscience
    Leverage the world’s largest collection of highly-characterized PDX models. Patient-derived xenografts (PDX) models offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, ...

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