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DeadEnd Colorimetric TUNEL System
DeadEnd Colorimetric TUNEL System from Promega
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Citations:
(173)
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DeadEnd Colorimetric TUNEL System
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Description
A modified TUNEL Assay designed for simple, rapid detection of apoptotic cells in situ at the single-cell level. Measures nuclear DNA fragmentation
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
DeadEnd Colorimetric TUNEL System
Company
Promega
Price
Supplier Page
View Company Product Page
Catalog Number
G7360
Quantity
20 reactions
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Promega
2800 Woods Hollow Rd
Madison
,
WI
53711
United States
Phone
: Tel: +1 (608) 274-4330
Fax: +1 (608) 277-2516
Email: custserv@promega.com
techserv@promega.com
Company Profile
Website:
http://www.promega.com
Citations (173)
(1)
HSD17B7 Counters Bone Loss in Estrogen Deficiency via Estrogen Receptor Stabilization and Mediates the Effect of Raloxifene
MedComm (2020)
January 31, 2026
Junyue Zhang, Yiping Song, Jeong-Hyun Koo, Si Chen, Kyu Yun Jang, Sun-Jung Yoon, Jung Ryul Kim, Young Jae Moon
Reactive Oxygen Species Following the manufacturer's instructions, a
DeadEnd colorimetric TUNEL system
(
G7360
,
Promega
Madison, WI, USA) was used to assess apoptosis in
CD11b
+
osteoclasts
. The nuclei were stained
(2)
RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target
Cancer Communications
October 16, 2025
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu,
et al.
caliper. 2.17 Terminal deoxynucleotidyl transferase
dUTP
nick end
labeling
(
TUNEL
)
staining
TUNEL
(#
G7360
,
Promega
) was used to
measure
apoptotic cells in paraffin‐embedded
mouse
tumor
tissues. Briefly, paraffin
(3)
Metabolite-enhanced normothermic machine perfusion improves kidney transplant viability
JCI Insight
September 23, 2025
Jan Czogalla, Fabian Hausmann, Simon Lagies, Sydney E. Gies, Sabrina Christiansen, Nico Kaiser, Fabian Haas, Yusuke Okabayashi, Dominik Kylies, Smilla Hofmann,
et al.
μm thick) were cut from tissue samples embedded in paraffin. The
Deadend Colorimetric TUNEL System
(
G7130
,
Promega
) was used according to the manufacturer’s specifications on
paraffin-embedded tissue
samples.
(4)
Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development
The FEBS Journal
September 1, 2025
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki,
et al.
deoxynucleotidyl transferase
dUTP
nick end
labeling
(
TUNEL) assay
A DeadEnd Colorimetric
TUNEL assay
kit (
Promega
—
G7360
, Madison, WI, USA) was used to detect apoptosis in Hmgcr
knockdown
cells. Scrambled and Hmgcr
shRNA
(5)
Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer
EMBO molecular medicine
July 1, 2025
McCabe M, Bhattacharyya R, Sereda R, Santiago-Fernández O, Khawaja RR, Diaz A, Lindenau K, Ozturk DG, Garner TP, Sidoli S,
et al
.
performed as above. Apoptotic cell death was visualized in tissue sections using
TUNEL
staining
(
Promega
,
G7130
) and the percent of positive cells in full sections was evaluated using QuPath Positive Cell Detection. Histopathology
(6)
Micronutrient antioxidant supplementation alleviates Valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway
Redox Biology
May 29, 2025
Muhammad Arif Asghar, Bing Wan, Lu Li, Jie Zhang, Shixin Tang, Hang Han, Yuanyuan Yang, Long Chu, Qian Zhang, Xiao Zhang,
et al.
was performed to detect apoptotic
germ cells
in testicular sections using an
apoptosis detection
kit (
G7130
,
Promega
) according to the manufacturer's protocol.
TUNEL
-positive cells and total cells were observed
(7)
Baoshentongluo Formula relieves podocyte injury in diabetic kidney disease through regulating mitophagy via PINK1/Parkin signaling pathway
Front Endocrinol (Lausanne)
May 23, 2025
Yanyu Pang, Lei Tian, Yufei Liu, Yifan Guo, Jingwen Zhao, Yutong Wang, Mengdi Wang, Wenjing Zhao
transferase-mediated
dUTP
-biotin nick end labelling analysis In vivo, the Dead-End™ Colorimetric
TUNEL
System (
G7130
/G7160,
Promega
, WI, USA) was used to detect apoptotic glomerular cells. The embedded renal sections
(8)
Growth of the maternal intestine during reproduction
Cell
May 15, 2025
Tomotsune Ameku, Anna Laddach, Hannah Beckwith, Alexandra Milona, Loranzie S. Rogers, Cornelia Schwayer, Emma Nye, Iain R. Tough, Jean-Louis Thoumas, Umesh Kumar Gautam,
et al.
(apoptosis) was performed on paraffin-embedded sections with
DeadEnd Colorimetric TUNEL System
kit (
Promega
,
G7130
), following manufacturer’s instructions.
Immunofluorescence (IF
)
Immunofluorescence
was performed
(9)
Microplastics Accumulation Induces Kynurenine-Derived Neurotoxicity in Cerebral Organoids and Mouse Brain
Biomolecules & Therapeutics
May 1, 2025
Sung Bum Park, Jeong Hyeon Jo, Seong Soon Kim, Won Hoon Jung, Myung Ae Bae, Byumseok Koh, Ki Young Kim
following a previously described protocol (Jeong et al., 2024). The
DeadEnd Colorimetric TUNEL System
(
G7360
,
Promega
) was used. Statistical analysis Data are presented as the mean ± standard error of the mean
(10)
Applying Ultrasound to Mechanically and Noninvasively Sensitize Prostate Tumors to TRAIL-Mediated Apoptosis
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
April 1, 2025
Fabiano AR, Newman MW, Dombroski JA, Rowland SJ, Knoblauch SV, Kusunose J, Gibson-Corley KN, Kaufman BG, Ren L, Caskey CF,
et al
.
using Triton X‐100 (9284, St. Louis, MO) for 5 min. Slides were incubated with Equilibration Buffer (
G7130
,
Promega
, Madison, WI) for 5 min, followed with the TdT reaction mix (
G7130
, Promega, Madison, WI) for
(11)
Roles of Necroptosis, Apoptosis, and Inflammation in Colorectal Carcinogenesis: A Longitudinal Human Study
Cancer Prevention Research
February 3, 2025
Timothy Su, Xiangzhu Zhu, Yong Li, Chang Yu, Xinqing Deng, Eugene Shubin, Lifang Hou, Jing Zhao, Lei Fan, Heping Zhang,
et al.
BAX
, we detected apoptosis using the Promega DeadEnd™ Colorimetric
Apoptosis Detection
System (Cat#
G7130
;
Promega
BioScience, San Luis Obispo, CA), a modified
TUNEL assay
. Human liver and TMA control tissues
(12)
The HRAS-binding C2 domain of PLCη2 suppresses tumor-like synoviocytes and experimental arthritis in rheumatoid arthritis
Experimental & molecular medicine
February 1, 2025
Jeon HM, Noh HS, Jeon MG, Park JH, Lee YS, Seo G, Cheon YH, Kim M, Han MK, Park JY,
et al
.
and immunohistochemistry
(
IHC
)). For
TUNEL
staining
, we used the
DeadEnd Colorimetric TUNEL system
(
Promega
,
G7130
) following the manufacturer’s instructions. In brief, the slides were incubated in permeabilization
(13)
Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
February 1, 2025
Liu BHM, Lin Y, Long X, Hung SW, Gaponova A, Ren F, Zhavoronkov A, Pun FW, Wang CC.
stromal cell
population and murine lesions were determined by
DeadEnd Colorimetric TUNEL System
(
Promega
,
G7130
) based on the manufacturer's protocol. Statistical Analysis Statistical analyses were performed by
(14)
Intestinal mucosal turnover in germ-free piglets infected with E. coli
Journal of Molecular Histology
February 1, 2025
Štefan Tóth, Zuzana Fagová, Monika Holodová, Kristína Čurgali, Eva Mechírová, Alexandra Kunová, Milan Maretta, Radomíra Nemcová, Soňa Gancarčíková, Marianna Danková
paraffin 4 µm thick sections was undertaken, using the
TUNEL assay
(DeadEnd TM Colorimetric
TUNEL
System,
G7360
,
Promega
; Madison, Wisconsin, USA) according to the manufacturer’s instructions. The nuclei were counterstained
(15)
Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Exp Hematol Oncol
January 12, 2025
Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua,
et al.
out of the total cells in each field.
TUNEL assay
DeadEnd™ Colorimetric TUNEL System
(
Promega
, USA,
G7130
) was used to detect late apoptotic cells in the harvested
tumor
tissues. 5 µm FFPE sections were processed
(16)
An endogenous aryl hydrocarbon receptor ligand induces preeclampsia‐like phenotypes in rats
The Journal of Physiology
December 9, 2024
Ying‐Jie Zhao, Chi Zhou, Si‐Yan Zhang, Jay S. Mishra, Hui‐Hui Li, Wei Lei, Kai Wang, Sathish Kumar, Jing Zheng
colorimetric terminal deoxynucleotidyl transferase
dUTP
nick end labelling (
TUNEL
) system (cat. no.
G7130
,
Promega
, Madison, WI, USA). The deparaffinized tissue sections were fixed in 10% buffered formalin,
(17)
XAF1 antagonizes TRIM28 activity through the assembly of a ZNF313-mediated destruction complex to suppress tumor malignancy
Mol Biomed
November 13, 2024
Jang SH, Choi HW, Ahn J, Jang S, Yoon JH, Lee MG, Chi SG.
in xenograft
tumor
tissues was carried out using a
DeadEnd™ Colorimetric TUNEL System
Kit (
Promega
#
G7360
).
Immunoblot
and immunoprecipitation
assay
Antibodies specific for
XAF1
(SC-19194, SC-374378, SC-398012
(18)
Spatial distribution of tumor-associated macrophages in an orthotopic prostate cancer mouse model
Pathology and Oncology Research
April 16, 2024
Korie A. Grayson, Joshua D. Greenlee, Lauren E. Himmel, Lauren A. Hapach, Cynthia A. Reinhart-King, Michael R. King
(Cat#T9284,
Sigma-Aldrich
, St. Louis, MO) for 5 min. Slides were incubated with Equilibration Buffer (#
G7130
,
Promega
, Madison, WI, United States) for 5 min, followed with the TdT reaction mix (#
G7130
, Promega)
(19)
Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation
Redox Biology
April 1, 2024
Liang Wang, Yang Qiao, Jingzhi Yu, Qihao Wang, Xinyu Wu, Qiqi Cao, Zeyu Zhang, Zhen Feng, Huan He
routinely fixed, dehydrated, embedded in paraffin, and sectioned. The slices were stained with
TUNEL
(
G7360
,
Promega
) following the manufacturer's instructions and observed under a microscope (BX63 Olympus) as
(20)
Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis
International journal of cancer
February 15, 2024
Yu Z, Dong X, Song M, Xu A, He Q, Li H, Ouyang W, Chouchane L, Ma X.
BX60 Upright Microscope. A tissue
apoptosis assay
was conducted using the
TUNEL assay
kit (
Promega
,
G7360
).
Immunohistochemical staining
(
IHC
) analysis was conducted by two independent pathologists who were
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DeadEnd Colorimetric TUNEL System from Promega
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