Fig 1: expression profile of proteins involved in certain aspects of cancer development such as cell proliferation, glycolytic metabolism, and cell invasion. (A) Total protein extracts from control and transduced HaCaT cells were obtained using a specific lysis buffer (Lysis buffer 17) (R&D Systems, Catalogue # 895943) included in the array kit. The relative expression levels of three proteins involved in cell proliferation and metabolism pathways (FGF basic, Enolase 2, and Fox01/FKHR) in HaCaT transduced and co-transduced cells compared to that in control cells is shown. (B) Relative expression levels of proteins expressed as mean spot pixel density that are involved in cell invasion (uPA, and CapG) and one protein involved in oxidative stress responses (HO-1/HMOX1) are shown for HaCaT transduced and co-transduced cells compared to those of control cells as assessed by the Human XL Oncology Array Kit (R&D Systems, MN, USA, ARY026). Averages ± standard deviations (SDs) of two independent experiments are shown. A two-way analysis of variance (ANOVA) test was conducted to assess statistical significance among groups along with Dunnett post-hoc test for intra-group comparison. (*) p < 0.05, (**) p < 0.01, (***) p < 0.001.