Mitochondrial ToxGlo Assay G8000 from Promega

Product Specs
ItemMitochondrial ToxGlo Assay
CompanyPromega
Price Supplier Page View Company Product Page
Catalog NumberG8000
Quantity10ml

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Promega

2800 Woods Hollow Rd

Madison, WI 53711

United States

Phone: Tel: +1 (608) 274-4330
Fax: +1 (608) 277-2516

Email: custserv@promega.com
techserv@promega.com

Company Profile

Website: http://www.promega.com

(1) Loss of HuD Sensitizes Neuroblastoma Cells to Palmitate-Driven Stress-Induced Premature Senescence via PPARα Downregulation and FAO ImpairmentCellsFebruary 7, 2026Seungyeon Ryu, Jiyoon Seo, Ye Eun Sim, Se Hoon Jung, Wei Zhang, Seung Min Jeong, Eun Kyung Leepotential (ΔΨm) were determined by using a Mitochondrial ToxGlo™ Assay (Promega, Madison, WI, USA; G8000) and a JC-1 Mitochondrial Membrane Potential Assay Kit (Abcam Plc., Cambridge, UK; ab113850), respectively,

(2) Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancerCell Death DiscoveryJanuary 19, 2026Silvia Sabbioni, Paola Guerriero, Ram C. Shankaraiah, Laura Masatti, Angelo Michilli, Cristian Bassi, Lucilla D’Abundo, Farzaneh Moshiri, Bruno De Siena, Edi Simoni, et al.ECAR were performed on Seahorse XFe/XF extracellular flux analyzers. The Mitochondrial ToxGlo™ assay (G8000, Promega, Madison, WI, USA) was used to evaluate mitochondrial function through differential measurement

(3) AUF1 Restrains Hepatocyte Senescence by Maintaining Mitochondrial Homeostasis in AML12 Hepatocyte ModelCellsDecember 26, 2025Myeongwoo Jung, Sukyoung Han, Seungyeon Ryu, Seongho Cha, Ye Eun Sim, Se Hoon Jung, Hyosun Tak, Wook Kim, Eun Kyung Leemembrane potential (Δψm) were analyzed using the Mitochondrial ToxGlo™ Assay (Promega Corporation; G8000) and the JC-1 Mitochondrial Membrane Potential Assay Kit (Abcam Plc.; ab113850), respectively, according

(4) Small peptide P110 mitigates axonal degeneration of SPG15 patient iPSC-derived neurons by targeting mitochondrial dysfunctionNeurobiology of DiseaseDecember 1, 2025Bavavarshini Tamilselvam, Gitika Thakur, Ruth Mathew, Eric Chai, Jose Lopez, Zhenyu Chen, Weihai Zhan, Craig Blackstone, Xue-Jun Limitochondrial function and toxicity, we employed the Promega Mitochondrial ToxGlo™ assay (Promega, USA #G8001). This assay measures cellular membrane integrity and ATP levels to evaluate potential mitochondrial

(5) Heat‐Induced Pathophysiological and Metabolic Changes at the Feto‐Maternal Interface Predisposing to Preterm BirthThe FASEB JournalNovember 30, 2025Isidore Mushimiyimana, Lauren Richardson, Thomas D. Horvath, Vladislav Orlovsky, Brinley Harrington, Italo Rodrigo Calori, Ananth Kumar Kammala, Ramkumar MenonAssay Relative changes in mitochondrial ATP levels were quantified using the Mitochondrial ToxGlo™ Assay (Cat # G8000, Promega) according to the manufacturer’s instructions. DECs and AECs cultured in 96-well plates were

(6) New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's diseaseAlzheimers Res TherJuly 23, 2025Aneta Houfková, Monika Schmidt, Ondřej Benek, Ivo Fabrik, Rudolf Andrýs, Lucie Zemanová, Ondřej Soukup, Kamil Musílek10 M instrument. Mitochondrial toxicity determination A Mitochondrial ToxGlo Assay kit (Promega, G8000) was used to determine the effect of protein overexpression (HSD10 or APPSwe/Ind) on mitochondrial fitness.

(7) Extracellular RNA mediates iron-induced toxicity and inflammatory signalling in hepatic cellsToxicology ReportsJune 1, 2025Sana Raza, Archana Tewari, Sangam Rajak, Pratima Gupta, Rohit A. SinhaFeCl3 in the presence or absence of RNase1. A mitochondrial ATP detection assay kit (Promega (Cat #G8001), Madison, WI, USA) was used to detect ATP as per manufacturer’s protocol. ATP was measured by adding

(8) Hepatotoxicity evaluation method through multiple-factor analysis using human pluripotent stem cell derived hepatic organoidsSci RepMarch 28, 2025Dae-Seop Shin, Jung Yoon Yang, Ha Neul Jeong, Seon Ju Mun, Hyunwoo Kim, Myung Jin Son, Myung Ae Baemitochondrial function Mitochondrial function was measured using the Mitochondrial ToxGlo™ Assay (Promega, #G8000) according to the manufacturer’s instructions. Cells cultured in 96-well plates for 72 h were incubated

(9) Splicing dysregulation in glioblastoma alters the function of cell migration‐related genesGliaFebruary 1, 2025Minu Seong, Pedro Bak‐Gordon, Zhaoqi Liu, Peter D. Canoll, James L. Manleythree times. Mitochondrial respiratory function assay A Mitochondrial ToxGlo™ Assay kit (Cat. No. G8000) was purchased from Promega. 1.0×104 HeLa-Cas9, HeLa-FLNAΔH and HeLa-FLNCΔH cells were seeded in a 96

(10) Secretory mitophagy: an extracellular vesicle-mediated adaptive mechanism for cancer cell survival under oxidative stressFrontiers in Cell and Developmental BiologyJanuary 30, 2025Purva V. Gade, Angela Victoria Rojas Rivera, Layla Hasanzadah, Sofie Strompf, Thomas Raymond Philipson, Matthew Gadziala, Atharva Tyagi, Arnav Bandam, Rithvik Gabbireddy, Fatah Kashanchi, et al.Cell Viability Assay for 12 h at 37°C. After treatment, the Mitochondrial ToxGlo™ assay (Promega, Cat. #G8000) was performed according to the manufacturer’s instructions. Approximately 20 µL of assay reagent was

(11) Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cellsCell Communication and SignalingNovember 12, 2024Laura Schmitt, Karina S. Krings, Andre Wolsing, Xabier Buque, Marcel Zimmermann, Hector Flores-Romero, Thomas Lenz, Ilka Lechtenberg, Christoph Peter, Björn Stork, et al.detection of changes in cellular ATP-levels, the mitochondrial ToxGlo™ assay (Promega, Mannheim, Germany; #G8000) was performed according to the manufacturer’s instructions. To enhance the detection sensitivity of

(12) Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicityDNA Repair (Amst)August 1, 2024Kate M. Saville, Rasha Q. Al-Rahahleh, Aisha H. Siddiqui, Morgan E. Andrews, Wynand P. Roos, Christopher A. Koczor, Joel F. Andrews, Faisal Hayat, Marie E. Migaud, Robert W. Sobolintegrity and ATP measurements were determined using multiplex Mitochondrial ToxGlo Assay (Promega, Cat# G8000), according to the manufacturer’s instructions. 2.10 Quantitative Real-Time PCR (qRT-PCR) The expression

(13) Senescent glia link mitochondrial dysfunction and lipid accumulationNatureJune 13, 2024China N. Byrns, Alexandra E. Perlegos, Karl N. Miller, Zhecheng Jin, Faith R. Carranza, Palak Manchandra, Connor H. Beveridge, Caitlin E. Randolph, V. Sai Chaluvadi, Shirley L. Zhang, et al.function assay The ratio of ATP/cytotoxicity was determined using the Promega Mitochondrial ToxGlo Assay (G8001). The manufacturer’s instructions were followed. Assay lysates consisted of individual dissected fly

(14) Neuroprotective and Disease-Modifying Effects of the Triazinetrione ACD856, a Positive Allosteric Modulator of Trk-Receptors for the Treatment of Cognitive Dysfunction in Alzheimer's DiseaseInternational journal of molecular sciencesJuly 6, 2023Parrado Fernandez C, Juric S, Backlund M, Dahlström M, Madjid N, Lidell V, Rasti A, Sandin J, Nordvall G, Forsell P.solution) was acquired from TCI Europe (Zwijndrecht, Belgium). The mitochondrial ToxGlo™ assay kit (G8001) was purchased from Promega Corporation (Madison, WI, USA). The PathHunter Detection Kit (93-0001) was

(15) RIP140-Mediated NF-κB Inflammatory Pathway Promotes Metabolic Dysregulation in Retinal Pigment Epithelium CellsCurrent Issues in Molecular BiologyNovember 21, 2022Zeli Guo, Yuli Shen, Jianwen Zhong, Zhuoyun Li, Qi Guo, Xiangchao Yao, Yandong Wang, Wenyu WuII enzyme. Measurements were performed according to the manufacturer’s instructions (Promega, cat# G8000, Fitchburg, WI, USA). 2.5. Western Blotting Assay After various treatments, ARPE-19 cells were washed

(16) The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolismCell death & diseaseNovember 8, 2022Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, et al.cellular ATP levels were performed using the mitochondrial ToxGlo™ assay (Promega, Mannheim, Germany; #G8000) according to manufacturer’s instructions. To increase the sensitivity for the detection of mitotoxins,

(17) Screening for anti-adipogenic, pro-lipolytic and thermogenic plant extracts by models associating intestinal epithelial cells with human adipose cellsEuropean Journal of NutritionJune 1, 2022Damien Guillemet, Chloé Belles, Aurélie Gomes, Vincent Azalbert, Mathilde André, Nourdine Faresse, Rémy Burcelin, Jean-Michel Lagarde, Danièle Lacasa, Mayoura Kéophiphathnon-adipogenic differentiation medium, using a luminescent ATP Detection Reagent (Mitochondrial ToxGloAssay, G8000, Promega). The mitochondrial toxin Rotenone (400 nM, R8875, Sigma) was used as a negative control. DAPI

(18) The Effect of Normoxic and Hypoxic U-87 Glioblastoma Paracrine Secretion on the Modulation of Brain Endothelial CellsCellsJanuary 14, 2022Mariam Rado, Brian Flepisi, David FisherGeneration Relative intracellular ATP levels were determined using the Mitochondrial ToxGlo™ kit (Promega (G8000), 2800 Woods Hollow Road, Madison, WI, USA). The Mitochondrial ToxGlo™ assay was conducted according

(19) The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and DepressionCellsDecember 29, 2021Santos SS, Moreira JB, Costa M, Rodrigues RS, Sebastião AM, Xapelli S, Solá S.Inc.). 2.7. ATP Measurement ATP content was assessed by performing the Mitochondrial ToxGlo™ assay (G8001; Promega Co., Madison, WI, USA), following the manufacturer’s instructions. ATP Detection Reagent was

(20) Differential Effects of Normoxic versus Hypoxic Derived Breast Cancer Paracrine Factors on Brain Endothelial CellsBiology (Basel)November 27, 2021Mariam Rado, Brian Flepisi, David Fisherintervals, relative intracellular ATP levels were determined using the Mitochondrial ToxGlo™ kit (Promega (G8000), address: 2800 Woods Hollow Road, Madison, WI, USA). The Mitochondrial ToxGlo™ assay was conducted

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Mitochondrial ToxGlo Assay

Mitochondrial ToxGlo Assay from Promega

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Mitochondrial ToxGlo Assay from Promega

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