Fig 1: The fold change alternations in mRNA levels. Bar diagram showing mRNA levels fold change of MCF-7 cells (I) and MCF-7 Xenograft mice (II) treated with single or combinatorial treatments relative to control. Bax, p53, caspase-3, caspase-9, Cytochrome C, and Bcl2 as apoptotic and anti-apoptotic genes (A), Beclin-1, ATG7, PI3K, and AKT as autophagic and growth proliferative signaling genes (B). Values are expressed as mean ± SE, n = 3. Data are presented as mean ± SE (error bar) of at least three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 compared with control (untreated -cells or -mice) groups.