Alpha-Klotho (Soluble) ELISA 27998 from IBL- America

Product Specs
ItemAlpha-Klotho (Soluble) ELISA
CompanyIBL- America
Price $895.00Supplier Page View Company Product Page
Catalog Number27998
Detection Range0 / 93.75 - 6000 pg/mL
Sensitivity6.15 pg/mL
Volume100 µL of properly diluted unknown / determination
Sample TypeSerum, plasma (EDTA, Heparin, Citrate), urine and cell culture supernatant
Regulatory StatusFor research use only, not for use in diagnostic procedures
ApplicationsELISA Kit
Quantity96 Determinations
ReactivityHuman
Assay Time1 hour incubation (RT) + 30 min. (RT) + 30 min. (RT) = 2 hours total incubation time
Storage2 - 8 °C

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IBL- America

8201 Central Ave NE Suite P

Minneapolis, Minnesota 55432

United States

Phone: 888-523-1246
763-780-2988

Company Profile

Website: http://www.ibl-america.com/

(1) Aging-related matrix metallopeptidase 10 and osteopontin levels are associated with pathology, cognitive decline, and age at onset in Alzheimer's diseaseAlzheimers DementApril 22, 2026Bryan Ng, Eleftheria Kodosaki, Elena Veleva, Ashvini Keshavan, Jonathan M. Schott, Amanda J. Heslegrave, Nick C. Fox, Henrik Zetterbergbuffer. Soluble Klotho was measured using an enzyme‐linked immunosorbent assay (ELISA) kit from IBL (27998‐IBL) before reading the plates on a SPECTROStar Omega microplate reader (BMG Lab Tech). The CSF dilution

(2) Markers of Mineral Metabolism in Children With CKD Stages 2 to 5DKidney International ReportsApril 1, 2026Anna Tschirner, Hannah Weber, Katharina Schermuly, Ineke Böckmann, Marko Pekic, Nele Kanzelmeyer, Jens Drube, Dieter Haffner, Maren Leifheit-Nestlerfragments (Quidel, Catalog # 60-6100, RRID: AB_2722648), sKlotho (Immuno Biological Laboratories, Catalog # 27998, RRID: AB_2750859) in plasma, and sclerostin (TECO Medical, Catalog # TE1023-HS, RRID: AB_2894880) in

(3) Reduced Circulating α‐Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac ArteriesJournal of the American Heart AssociationNovember 18, 2025Elias Hellou, Parvin Kalhor, Ali Babaie, Nadia Akhiyat, Negin Mahmoudi Hamidabad, Valentina Nardi, Matteo Manzato, Kai Nogami, Elizabeth Copley, Lilach O Lerman, et al.Laboratories Co., Ltd. MN 55432, USA) was used according to the instructions for use (IBL Code No. 27998). 34 Quality controls were included in each batch run (each plate) and monitored for acceptance. The

(4) Androgen receptor gene polymorphism and biological age markers in menScientific reportsOctober 31, 2025Żelaźniewicz A, Nowak-Kornicka J, Dąbrowski A, Pawłowski B.analysis. Serum soluble circulating Klotho (s-Klotho) levels were measured using a commercial kit (IBL® Code no 27998) and expressed in pg/ml. The inter-assay and intra-assay coefficients of variation were less than 11.4%

(5) Growth hormone treatment associates with improved circulating anti-aging protein Klotho and reduced arterial stiffness in children with CKDClinical Kidney JournalSeptember 1, 2025Stella Stabouli, Maren Leifheit-Nestler, Michael Föller, Martina Feger, Aysun K Bayazit, Anke Doyon, Lukasz Obrycki, Bruno Ranchin, Jun Oh, Dusan Paripovic, et al.iFGF23, 1,25 (OH)2D3, and IGF1. Enzyme-linked immunosorbent assay kits were used for serum sKlotho (#27998, Immuno-Biological Laboratories, Japan), plasma iFGF23 (#60–6600, Immutopics, San Clemente, CA, USA),

(6) Association between circulating Klotho levels and hypertension: insights from NHANES, Mendelian randomization, and an Asian cohortRen FailJuly 24, 2025Yu Fu, Mengling Peng, He Cai, Yaoting Zhang, Bing Li, Yang Zhengpoint available as a biomarker of biological age. The ELISA kit used in this study (IBL Japan, Cat# 27998) measures total soluble Klotho and does not distinguish between the shed and secreted isoforms. For

(7) Exercise attenuates bed rest-induced increases in insulin resistance while α-klotho increases in 55 to 65 year-old women and menSci RepJuly 24, 2025Carmelo J. Mastrandrea, Guy Hajj-Boutros, Vita Sonjak, Eric T. Hedge, Gilles Gouspillou, Richard L. Hughson, José A. Moraisintact FGF-23 (CY-4000 kit, Kainos Laboratories Inc., Tokyo, Japan), plasma human soluble α-klotho (No. 27998, IBL-America, Minneapolis, USA), uncarboxylated osteocalcin (LEGEND MAX™ Human ucOCN 446707 Kit, The

(8) Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover studyJ Transl MedJune 19, 2025Carolin Haberstroh Bekkos, Md Abu Jafar Sujan, Astrid Kamilla Stunes, Atefe Rafiee Tari, Norun Aagård, Cathrine Langlie Brobakken, Martin Siksjø Brevig, Unni Syversen, Eivind Wang, Mats Peder Mosticalled Klotho) assay kit (Immuno-Biological Laboratories Co, Ltd., Naka Fujioka-Shi, Gunma, Japan; Cat# 27998; RRID:AB_2750859; detection limit 6.15 pg \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym}

(9) Urinary Extracellular Vesicle Analysis Reveals Early Signs of Kidney Inflammation and Damage in Single Ventricle Paediatric Patients After Fontan OperationInt J NanomedicineMay 7, 2025Cristina Grange, Luca Deorsola, Beatrice Degiovanni, Dario Tomanin, Diego Prudente, Licia Peruzzi, Carlo Pace Napoleone, Benedetta Bussolatisubjects and 60 for patients). ELISA for Klotho An anti-human ELISA (Human soluble a-Klotho code 27998; Immuno-Biological Laboratories) was used to quantify Klotho levels within uEVs, according to the manufacturer’s

(10) Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort studyInternational Urology and NephrologyApril 1, 2025Pei-Shan Peng, Wei Luenzyme-linked immunosorbent assay (ELISA) sandwich technique. The Human Soluble α-Klotho Assay Kit (Code No. 27998, Immuno-Biological Laboratories Co., Ltd., Gunma, Japan) was used for detecting serum Klotho, whereas

(11) Young adults’ circulating FGF23 and α-klotho and their relationship with habitual dietary acid load and phosphorus intake during growthScientific ReportsNovember 13, 2024Luciana Peixoto Franco, Seyedeh-Masomeh Derakhshandeh-Rishehri, Ute Nöthlings, Michaela F. Hartmann, Christian Herder, Hermann Kalhoff, Stefan A. Wudy, Thomas Remercarboxyl-terminal (C-Term) portion of the FGF23 molecule. The human soluble α-klotho sandwich ELISA kit (IBL No. 27998; Immuno-Biological Laboratories Co., Ltd, Gunma, Japan) was used for the quantification of α-klotho.

(12) Association of elevated cerebrospinal fluid levels of the longevity protein α‐Klotho with a delayed onset of cognitive impairment in Parkinson's disease patientsEuropean Journal of NeurologyOctober 1, 2024Milan Zimmermann, Madeleine Fandrich, Meike Jakobi, Benjamin Röben, Isabel Wurster, Stefanie Lerche, Claudia Schulte, Shahrzad Zimmermann, Christian Deuschle, Nicole Schneiderhan‐Marra, et al.profiles A commercial enzyme‐linked immunosorbent assay kit (IBL International, Hamburg, Germany, Cat# 27998, LOT# 2C‐117) was used for the detection of α‐Klotho (in ng/mL). Single analyses were performed of 1:2

(13) Women With a History of Preeclampsia Exhibit Accelerated Aging and Unfavorable Profiles of Senescence MarkersHypertensionJuly 1, 2024Sonja Suvakov, Lisa E. Vaughan, Santosh Parashuram, Yvonne S. Butler Tobah, Muthuvel Jayachandran, Andrea Kattah, Alanna M. Chamberlain, Suzette J. Bielinski, Natasa Milic, Vesna D. Garovicdetermined using commercial ELISA (Alpha Klotho Human Soluble ELISA Assay kit, IBL-America. Inc, Cat#27998). The α-Klotho/Creatinine ratio was calculated by dividing concentrations of urinary α-Klotho by urinary

(14) Relationship between klotho and physical function in healthy agingScientific ReportsNovember 30, 2023Eliott Arroyo, Cecilia A. Leber, Heather N. Burney, Gayatri Narayanan, Ranjani Moorthi, Keith G. Avin, Stuart J. Warden, Sharon M. Moe, Kenneth Limserum using a well-validated solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) (Cat. No. 27998, Immuno-Biological Laboratories, Inc., Minneapolis, MN, USA)27. To eliminate inter-assay variance, all

(15) A Combined Biomarker That Includes Plasma Fibroblast Growth Factor 23, Erythropoietin, and Klotho Predicts Short- and Long-Term Morbimortality and Development of Chronic Kidney Disease in Critical Care Patients with Sepsis: A Prospective CohortBiomoleculesOctober 3, 2023Toro L, Rojas V, Conejeros C, Ayala P, Parra-Lucares A, Ahumada F, Almeida P, Silva MF, Bravo K, Pumarino C, et al.FGF23: 60-6600, Quidel Immutopics, San Diego, CA; EPO: DEP00, R&D Systems, Minneapolis, MN. Klotho: 27998, IBL-America, Minneapolis, MN, USA) according to manufacturer’s specifications. The inter-assay coefficient

(16) Birth size and the serum level of biological age markers in menScientific ReportsAugust 30, 2023Agnieszka Żelaźniewicz, Judyta Nowak-Kornicka, Bogusław Pawłowskilevel was measured with enzyme-linked immunosorbent assay (ELISA) using commercial kits (IBL® Code no 27998; with inter-assay and intra-assay coefficient of variation less than 11.4% and less than 3.5% respectively

(17) Serum α-Klotho associated with oral health among a nationally representative sample of US adultsFront Endocrinol (Lausanne)September 20, 2022Guo-Qiang Chen, Yao Duan, Jin-Feng Wang, Ying Lian, Xiu-Li Yinprotocol, serum α-klotho was assayed using a solid-phase sandwich enzyme-linked immunosorbent assay (ELISA 27998, IBL International, Japan). This assay is reported to have a sensitivity of 6 pg/mL. All sample analyses

(18) Serum α-KL, a potential early marker of diabetes complications in youth with T1D, is regulated by miRNA 192Front Endocrinol (Lausanne)August 5, 2022Zhenwei Gong, Pedro A. Pagán Banchs, Ye Liu, Haoyi Fu, Vincent C. Arena, Erick Forno, Ingrid Libman, Jacqueline Ho, Radhika MuzumdarNumber: PRO15100286). Serum KL level Serum α-KL level was determined using ELISA kit from IBL (Cat# 27998, Immuno-Biological Labs, Japan) according to the manufacturer’s instructions. The coefficient of variability

(19) Gender-specific soluble α-klotho levels as marker of GH deficiency in children: a case–control studyJournal of Endocrinological InvestigationJune 1, 2022V. Guarnotta, G. Pizzolanti, R. Petrancosta, S. Radellini, C. Baiamonte, C. Giordanoanalyzed using a commercial solid phase sandwich ELISA (Enzyme-linked Immunosorbent Assay) assay kit (cat.27998, Immuno-Biological Laboratoires Co., Fujioka-Shi, Japan). The normal measurement range was 93.75–6000

(20) Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humansEBioMedicineMarch 1, 2022Zhu Y, Prata LGPL, Gerdes EOW, Netto JME, Pirtskhalava T, Giorgadze N, Tripathi U, Inman CL, Johnson KO, Xue A, et al.diluted mouse urine (IBL America, #27601). Human urine α-Klotho was assayed by ELISA (IBL America, #27998, RRID:AB_2750859). Urine α-Klotho measurements are expressed as a function of urine volume, creatinine

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Alpha-Klotho (Soluble) ELISA from IBL- America

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Alpha-Klotho (Soluble) ELISA from IBL- America

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