Anti-POLE antibody GTX132100 from GeneTex

Product Specs
ItemAnti-POLE antibody
CompanyGeneTex
Price $169.00Supplier Page
Catalog NumberGTX132100
FormatPBS, 20% Glycerol, 0.025% ProClin 300
Gene NamePOLE
Molecular Weight262
Research AreaCell Biology
HostRabbit
Concentration1.45mg/ml
ReactivityHu, Ms
ClonalityPolyclonal
NCBI Gene AliasesFILS, IMAGEI, DNA polymerase epsilon, catalytic subunit, CRCS12, FILS, IMAGEI, POLE1, POLE1, CRCS12
NCBI Full Gene NameDNA polymerase epsilon, catalytic subunit
ApplicationsWB, IHC-p, ICC, IF
ImmunogenRecombinant protein encompassing a sequence within the N-terminus region of human POLE. The exact sequence is proprietary
Antibody TypePrimary Antibodies
IsotypeIgG
TargetPOLE
PurityPurified by antigen-affinity chromatography
Conjugate/TagUnconjugated
Quantity25 µl

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GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screensbioRxivJune 30, 2026Alexander-Hoi Nguyen, Vicky Li, Wei-Min Chen, Jacob Kimberg, Anthony J. Davis, David G. McFadden, Juan Manuel Povedanotag (D3H8Q) (Cell Signaling Technologies #13202), anti-GAPDH (GeneTex GTX627408), anti-PolE (GeneTex GTX132100), and anti-Msh2 [D24B5] XP rabbit mAb (#2017, Cell Signaling Technology). Primary antibodies were incubated

(2) Targeting DNA Polymerase Epsilon Induces Tumor Clearance and Activates an NF-κB-Mediated Inflammatory Response in Triple Negative Breast CancerCancer ResApril 21, 2026Elizabeth F. Sher, Kenji M. Fujihara, Anthony Tao, Paul Sastourne-Haletou, Diana Erenburg, Vladislav O. Sviderskiy, Hannan Mir, Triantafyllia Karakousi, Cynthia A. Loomis, Jiehui Deng, et al.Chk1 (Santa Cruz Biotechnology, Cat# sc-8408, RRID:AB_627257); antibody against POLE (GeneTex, Cat# GTX132100); antibodies against phospho-H2AX S139 (Cell Signaling Technology, Cat# 9718, RRID:AB_2118009), H2AX

(3) Functional Characterization of POLE1 Variant Fibroblasts Reveals Replication Stress and Increased Sensitivity to Genotoxic StressDiseasesMarch 4, 2026Enas Khdeda, Nora Naumann-Bartsch, Nawres Khdeda, Giulia Cramer, Laura S. Hildebrand, Paula Schiller, Paul Julian Wagner, Franziska Fahrmeier, Ulrike Hüffmeier, Stefanie Corradini, et al.Cambdrigde, UK; dilution 1:5000) and N-terminal binding anti-POLE1 (GeneTex, Irvine, CA, USA; Cat. No.GTX132100; dilution 1:2000). After thorough washing with TBST, appropriate secondary antibodies were applied for

(4) NFS1, together with FXN, protects cells from ferroptosis and DNA damage in diffuse large B-cell lymphomaRedox BiologyNovember 1, 2025Xue Shi, Yun Zhao, Hong-Yu Gao, Wei Yang, Jun Liao, Hui-Han Wang, Xiao-Tian Wang, Wei YanChina), POLA1 antibody (P09884, Zen-Bio, China), POLD1 antibody (DF3997, Affinity, China), POLE antibody (GTX132100, Genetex, China), GPX4 antibody (DF6701, Affinity, China), SLC7A11 antibody (R382036, Zen-bio, China),

(5) Targeting DNA Polymerase Epsilon Leads to Tumor Clearance and Activation of an NF-κB-mediated inflammatory response in Triple Negative Breast CancerbioRxivSeptember 23, 2025Elizabeth F. Sher, Kenji M. Fujihara, Anthony Tao, Diana Erenburg, Vladislav O. Sviderskiy, Hannan Mir, Triantafyllia R. Karakousi, Cynthia Loomis, Jiehui Deng, Kwok-Kin Wong, et al.TME. METHODS Reagents Used Antibodies against Chk1 (sc-8408) from Santa Cruz; antibody against POLE (GTX132100) from GeneTex, antibodies against pH2AX S139 (9718), H2AX (2595), pChk1 S345 (2348), phospho p65 S536

(6) A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substratesScience advancesAugust 9, 2024Mukhopadhyay U, Levantovsky S, Carusone TM, Gharbi S, Stein F, Behrends C, Bhogaraju S.,Santa Cruz Biotechnology Biotin,31852,Pierce Phospho NF-kB,3031,Cell Signaling Technology Calnexin,ab22595,Abcam POLE,GTX132100,GeneTex Annexin V,MAB3991-SP,R&D Systems Phospho Histone H2AX (Ser139),2577S,Cell Signaling Technology TRAF6,ab33915,Abcam HGS,ab72053,Abcam STAM,12434-1-AP,Proteintech

(7) Asymmetric distribution of parental H3K9me3 in S phase silences L1 elementsNatureNovember 1, 2023Li Z, Duan S, Hua X, Xu X, Li Y, Menolfi D, Zhou H, Lu C, Zha S, Goff SP, et al.

(8) Systematic discovery of mutation-directed neo-protein-protein interactions in cancerCellMay 26, 2022Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, et al.antibody,Proteintech,Cat# 12816-1-AP; RRID:AB_2129846 Rabbit polyclonal anti-POLE antibody,GeneTex,Cat# GTX132100; RRID:AB_2886567 Mouse Anti-Rabbit IgG (Light-Chain Specific) (D4W3E) mAb (HRP Conjugate),Cell signaling,Cat#

(9) Novel POLE mutations identified in patients with IMAGE-I syndrome cause aberrant subcellular localisation and protein degradation in the nucleusJournal of medical geneticsMay 9, 2022Nakano T, Sasahara Y, Kikuchi A, Moriya K, Niizuma H, Niihori T, Shirota M, Funayama R, Nakayama K, Aoki Y, et al.polyvinylidene difluoride membrane. The membrane was probed with antibodies against POLE (GeneTex, GTX132100), FLAG (Sigma-Aldrich, F1804), lamin A/C (Santa Cruz, 123243) and α-tubulin (Santa Cruz, 24534) followed

(10) Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase εMolecular cellNovember 19, 2020Sviderskiy VO, Blumenberg L, Gorodetsky E, Karakousi TR, Hirsh N, Alvarez SW, Terzi EM, Kaparos E, Whiten GC, Ssebyala S, et al.

(11) Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancerScientific reportsMay 19, 2020Chiu YF, Wu CC, Kuo MH, Miao CC, Zheng MY, Chen PY, Lin SC, Chang JL, Wang YH, Chou YT.

(12) Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed RatsBiomoleculesOctober 11, 2019García-Arroyo FE, Monroy-Sánchez F, Muñoz-Jiménez I, Gonzaga G, Andrés-Hernando A, Zazueta C, Juárez-Rojas JG, Lanaspa MA, Johnson RJ, Sánchez-Lozada LG.

(13) POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA ReplicationMolecular cellOctober 4, 2018Bellelli R, Belan O, Pye VE, Clement C, Maslen SL, Skehel JM, Cherepanov P, Almouzni G, Boulton SJ.polyclonal Anti POLE3,Bethyl,Cat#A301-245A; RRID: AB_890598 Rabbit polyclonal Anti POLE1,Genetex,Cat#GTX132100 Monoclonal ANTI-FLAG M2-Peroxidase (HRP) antibody produced in mouse,Sigma,Cat#A8592; RRID: AB_439702 "Donkey

(14) Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitorsCell reportsJanuary 1, 0001"Hill BR, Ozgencil M, Buckley-Benbow L, Skingsley SLP, Tomlinson D, Eizmendi CO, Agnarelli A, Bellelli R."

(15) "Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis"Molecular cellJanuary 1, 0001"Bellelli R, Borel V, Logan C, Svendsen J, Cox DE, Nye E, Metcalfe K, O'Connell SM, Stamp G, Flynn HR, et al."polyclonal Anti POLE3,Bethyl,Cat#A301-245A; RRID: AB_890598 Rabbit polyclonal Anti POLE,Genetex,Cat#GTX132100 Rat monoclonal anti GINS1,Fitzgerald,Cat#10R-1766; RRID: AB_10809593 Rabbit polyclonal anti-POLD1,Bethyl,Cat#A304-007A;

(16) Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axisCell reportsJanuary 1, 0001"Borel V, Boeing S, Van Wietmarschen N, Sridharan S, Hill BR, Ombrato L, Perez-Lloret J, Jackson D, Goldstone R, Boulton SJ, et al."Monoclonal Anti-POLE2,Abcam,Cat#ab57298; RRID: AB_2166739 Rabbit polyclonal Anti POLE,Genetex,Cat#GTX132100 Rabbit polyclonal anti-POLD1,Bethyl,Cat#A304-007A; RRID: AB_2620355 Mouse monoclonal anti-MCM2,BD Biosciences

(17) Validating the concept of mutational signatures with isogenic cell modelsNature communicationsJanuary 1, 0001"Zou X, Owusu M, Harris R, Jackson SP, Loizou JI, Nik-Zainal S."(C1, Santa Cruz), EXO1 (A302-639A, Bethyl Laboratories), FANCC (MABC524- clone 8F3, Millipore), POLE (GTX132100, GeneTex), Actin (A5060, SIGMA), NEIL1 (12145-1-AP, Proteintech), POLB (ab26343, Abcam), and MSH6 (D60G2,

(18) Stepwise requirements for polymerases δ and θ in theta-mediated end joiningNatureJanuary 1, 0001"Stroik S, Carvajal-Garcia J, Gupta D, Edwards A, Luthman A, Wyatt DW, Dannenberg RL, Feng W, Kunkel TA, Gupta GP, et al."(Abcam, 186406) 1:2,000; Actin (Novus, NB600–535) 1:10,000; HALO (Promega, G9211) 1:1,000; POLE (GeneTex, GTX132100) 1:2,000; FLAG (Sigma, F3165) 1:2,000); APEX2 (Novus, NB100–56625) 1:1,000; POLD2 (Thermo Scientific,

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Anti-POLE antibody

Anti-POLE antibody

Anti-POLE antibody

Anti-POLE antibody

Anti-POLE antibody from GeneTex

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Anti-POLE antibody from GeneTex

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