c-Myc (D84C12) Rabbit mAb 5605S from Cell Signaling Technology

Product Specs
Itemc-Myc (D84C12) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number5605S
Quantity100 µl
ApplicationsW, W-S, IF-IC
ReactivityH, M, R
TargetMyc
HostRabbit
NCBI Gene AliasesMRTL, MYCC, bHLHe39, c-Myc
ClonalityMonoclonal
NCBI Full Gene NameMYC proto-oncogene, bHLH transcription factor
Research AreaApoptosis
IsotypeIgG
CloneD84C12
Molecular Weight57-65

Questions and Answers

Can this c-Myc antibody be used for Western blotting in my experiments?

Yes, the c-Myc (D84C12) Rabbit mAb has been shown to be effective for use in Western blotting, as evidenced by its application in various studies, including those that analyzed protein expression levels in cancer models (, , ).

Is this antibody suitable for detecting c-Myc in human and mouse samples?

The c-Myc (D84C12) Rabbit mAb is reactive with human, mouse, and rat samples, making it suitable for studies involving these species.

Are there any specific studies that have utilized this antibody in the context of cancer research?

Yes, this antibody has been cited in multiple studies related to cancer, including its role in breast cancer progression and the regulation of cancer stem cell markers, as seen in research focusing on triple-negative breast cancer (, ).

What is the recommended dilution for using this antibody in immunocytochemistry?

While specific dilution recommendations for immunocytochemistry are not provided in the available literature, it is commonly used at a dilution of 1:1000 in similar applications, as indicated in various studies utilizing this antibody for protein detection (, ).

Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expressionJournal of Clinical InvestigationMay 1, 2026Wen Gu, Xun Wang, Ashley Solmonson, Ling Cai, Yi Xiao, Alpaslan Tasdogan, Jordan Franklin, Yuannyu Zhang, Hua Zhang, Aundrea K. Westfall, et al.performed using standard procedures with antibodies against c-MYC (Cell Signaling Technology, 9402 and 5605), Neurogenin-2 (Cell Signaling Technology, 13144), and TBP as a nuclear loading control (Cell Signaling Technology

(2) Endogenous protein tagging coupled with a CRISPR screening approach identifies UBE3C as a potential MYC oncogene regulatorSci RepApril 11, 2026Marcel Seibert, Nina Kurrle, Sifora Kaleab, Frank Wempe, Ivana von Metzler, Hubert Serve, Frank Schnütgenin a 1:20,000 dilution. GAPDH (Abcam (6C5), Mouse #ab8245), MYC (Cell Signaling (D84C12) Rabbit mAb #5605), MAX (Proteintech, Rabbit pAb, #10426-1-AP), Vinculin (Abcam (SPM227) Mouse mAb #ab18058), FBXW7 (Proteintech,

(3) Genome-wide profiling identifies the genetic dependencies of cell death following EGFR inhibitionJ Biol ChemApril 2, 2026Sydney A. Porto, Gavin A. Birdsall, Nicholas W. Harper, Megan E. Honeywell, Scott M. Leighow, Tiana E. Naylor, Kelly M. Ward, Mika K. Wesley, Justin R. Pritchard, Michael J. Leeperformed using the LiCOR Odyssey CLx infrared scanner. PTEN (9188T), BIM (2933), Mcl-1 (5453S), and MYC (5605S) rabbit monoclonal antibodies were purchased from Cell Signaling Technologies. β-actin mouse monoclonal

(4) Comparative effectiveness of seven major human let-7-5p isoforms to modulate target gene expression in liver cellsDrug Metabolism and DispositionApril 1, 2026Joseph M. Cronin, Mei-Juan Tu, Yimei Wang, Ai-Ming Yuincubated overnight (4°C) with primary antibodies against c-MYC (1:1,000; Cell Signaling Technology Cat# 5605), PD-L1 (1:1,000; Cell Signaling Technology Cat# 86744), CDK6 (1:1,000; Santa Cruz Biotechnology; Cat#

(5) Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumorCell ReportsMarch 24, 2026Andrew M. Fleming, Carolyn M. Jablonowski, Hongjian Jin, Siwei Zhang, Surbhi Sona, Ha Won Lee, Karissa M. Dieseldorff Jones, Changde Cheng, Beisi Xu, Christopher L. Morton, et al.RRID:AB_3105780" "CMYC (Western blot, monoclonal rabbit; 1:1000 dilution)",Cell Signaling Technology,"cat# 5605, RRID:AB_1903938" Horseradish peroxidase-conjugated anti-rabbit (1:5000 dilution; secondary antibody),Thermo Fisher

(6) Targeting Activated Pathways in Doxorubicin-Resistant TNBC Alters Signaling, Survival and EMT: A Double-Edged SwordInt J Mol SciMarch 19, 2026Irem Dogan Turacli, Sahika Cingir Koker, Kubra Paspal Eroglu, Banu YalcinCST #4370, ERK CST #4695, BIM CST #2819, BAX CST #2772, BCL-XL CST #2762, PARP CST #9532, c-MYC CST #5605, CYCLIND1 CST #2922, VIMENTIN CST #5741, E-CADHERIN CST #3195, and GAPDH CST #2118. 4.7. Wound Healing

(7) Cathepsin E drives colorectal cancer progression and immune evasion via ZNF326 ADP-ribosylation and TGF-β/SMAD activationJournal of Translational MedicineMarch 14, 2026Huan Zhang, Jie Feng, Mengxin Zhu, Tongguo Shi, Qinhua Xiantibodies used include PAR/pADPr antibody (R&D, 4335-MC-100), Myc antibody (Cell signaling technology, 5605), DYKDDDDK antibody (Proteintech, 66008–4-Ig), CTSE antibody (Abcam, ab89414), DNMT3A (Proteintech,

(8) Targeting Prolyl 3-hydroxylase 1 inhibits pancreatic cancer progression and macrophage immunityNature CommunicationsMarch 13, 2026Panzhu Bai, Chengmin Liu, Changying Fu, Renwei Cai, Yanyan Ding, Meiling Quan, Yuhao Ye, Ziyang Zhang, Yuan Li, Yanfen Xu, et al.anti-P3H1 (Abcam, ab244326, 1:1000), rabbit anti-PLK1 (CST, 4513S, 1:1000), rabbit anti-c-Myc (CST, 5605S, 1:1000), rabbit anti-CyclinD1 (HUABIO, ET1601-31, 1:1000), rabbit anti-CXCL1 (Abcam, ab86436, 1:500),

(9) Combining anti-gene γPNA with small molecules and RNA inhibitors: A strategy to enhance anti-tumor efficacyMolecular Therapy Nucleic AcidsMarch 12, 2026Sai Pallavi Pradeep, Brooke Elizabeth DiVasto, Peter M. Glazer, Raman Bahaltransferred to a polyvinylidene fluoride membrane. Primary antibodies for c-MYC (Cell Signaling Technology, #5605) and EZH2 (Cell Signaling Technology, #5246) were applied using a rabbit monoclonal antibody diluted

(10) PKM2 phosphorylation by c-SRC activates glycolysis and metastasis with the stimulation of tumor-associated macrophagesCell Communication and SignalingMarch 12, 2026Da Song, Haijie Li, Jialu Xu, Wenli Zhan, Yaqi Chen, Xuelai Luo, Guihua Wang, Xingrui Li, Junbo Hu, Jingqin LanCell Signaling Technology Cat#3724), Lamin B1 (Cell Signaling Technology Cat#13435), c-Myc (Cell Signaling Technology Cat#5605), LDHA (Cell Signaling Technology Cat#3582), GLUT1 (Cell Signaling Technology Cat#73015), Vimentin (Cell Signaling Technology

(11) Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineageNat CommunMarch 9, 2026Irina Poverennaya, Aliia Murtazina, Lei Li, Lorena Maili, Lukas Sourada, Luis Fernando Montano-Gutierrez, Rozalina Galimullina, Tobias Steinschaden, Marketa Kaiser, Tomas Zikmund, et al.(1:1000, Abcam, #ab19898), rabbit anti-HTR3A (1:1000, Abcam, #ab13897), rabbit anti-c-MYC (1:1000, CST, #5605), rabbit anti-MCL-1 (1:1000, CST, #94296), mouse anti-cyclin D1 (1:1000, Exbio, #11-535-C100), rabbit

(12) Insulin and Insulin-like Growth Factor 1 Signaling as a Modulator of MYC Expression in the Meibomian GlandBiomedicinesMarch 4, 2026Cynthia Verling, Autumn Berlied, Cornelia Petersonparaformaldehyde (PFA) and subjected to routine immunocytochemistry using an anti-c-MYC antibody (catalog #5605; Cell Signaling Technology, Danvers, MA, USA) diluted 1:400, an anti-IGF1R antibody (catalog #bs-4985R;

(13) FBXW7 Targets the SPT6-ΔNp63 Axis for Degradation to Inhibit Esophageal Tumorigenesis Induced by 4-Nitroquinoline N-OxideMedComm (2020)March 4, 2026Jiagui Zhang, Lu Yin, Xiahong You, Xiufang Xiong, Yi SunNEDD8 (Abcam, ab81264), GSK3α/β (Cell Signaling Technology, 5676), c‐MYC (Cell Signaling Technology, 5605), p‐Ser/Thr‐Pro (05‐368, Upstate), FLAG (Sigma‐Aldrich, F1804), HA (Sigma‐Aldrich, A2095), β‐Actin (HUABIO,

(14) Aggressive Cholesterol Lowering Normalizes Atherosclerosis Regression in Jak2V617F MiceJournal of Lipid ResearchFebruary 18, 2026Brian D. Hardaway, Trevor P. Fidler, Mojdeh Tavallaie, Cheng-Chieh Hsu, Sandra Schiavone, Tong Xiao, Ranran Wang, Nan Wang, Alan R. Tall(AIM2) (Abcam, ab119791, 1:250), Cleaved GasD (Cell Signaling, 10137, 10 μg/ml), c-Myc (Cell Signaling, 5605, 5.76 μg/ml), Ki67 (Abcam, ab15580, 9 μg/ml), MAC2 (Cedarlane, CL8942AP 1 μg/ml), MAC2 conjugated to

(15) S6K1 Modulates STAT3 Activation to Promote Resistance to Radiotherapy in Lung CancerInternational Journal of Molecular SciencesFebruary 17, 2026Ali Calderon-Aparicio, Noelle Francois, Tyler Grenda, Shan Xu, Olugbenga Okusanya, Jun He, Nicole L. SimoneSTAT3 (Cell Signaling Technology Cat# 4904, RRID:AB_331269), c-myc (Cell Signaling Technology Cat# 5605, RRID:AB_1903938). All antibodies were diluted according to the manufacturer’s recommendations. 4.6.

(16) A Combination of Xanthohumol and Ursolic Acid in the Diet Leads to Synergistic Inhibition of Prostate Cancer ProgressionMolecular CarcinogenesisFebruary 10, 2026Rachel Clark, Achinto Saha, G. Lavender Hackman, Chelsea A. Friedman, Ruggiero Gorgoglione, Stefano Tiziani, John DiGiovanni(Cell Signaling, 3387), p‐RbS807/811 (Cell Signaling, 9308), Rb (Invitrogen, MA5‐11387), c‐MYC (Cell Signaling, 5605), ATF4 (Cell Signaling, 11815), CHOP (Cell Signaling, 2895), vinculin (Cell Signaling, 13901), GAPDH

(17) PRKD1/EIF5A/β-catenin axis inhibits tumorigenesis and metastasis in non-small-cell lung cancerClin Exp MedFebruary 8, 2026Yu Wang, Mengyu Zhang, Lijun Fang, Jiajia Qu, Chen Huo, Rui Li, Jie Yao, Yiqing Qu1:1000), p-β-catenin (CY9969, abways, 1:1000), β-catenin (8480, Cell Signaling Technology, 1:1000), c-myc (5605, Cell Signaling Technology, 1:1000), c-Jun (9165, Cell Signaling Technology, 1:1000), EIF5A (CY5637,

(18) Deciphering Multitarget Mechanisms of Cardiac Glycosides in Acute Myeloid Leukemia Using a Network Pharmacology and Molecular DockingDrug Design, Development and TherapyFebruary 7, 2026Parinya Samart, Jirarat Poohadsuan, Supasorn Chanthateyanonth, Surapol Issaragrisil, Sudjit Luanpitpong(Ser2448) (#5536), mTOR (#2983), Raptor (#2280), Rictor (#2114), G-β-L (#3274), COX-2 (#12282), and c-Myc (#5605) (Cell Signaling Technology). After washing, membranes were incubated with HRP-conjugated secondary

(19) Synergistic targeting of the ARID2–MYC axis by pomalidomide and panobinostat overcomes intrinsic IMiD resistance in multiple myelomaScientific ReportsFebruary 5, 2026Junichi Yamamoto, Tomoko Asatsuma-Okumura, Takumi Ito, Yoshiko Iwai, Hiroshi Handa, Yuki Yamaguchiml−1), anti-IKZF3 (sc-101982, Santa Cruz, 2 µg ml−1), anti-ACTB (ab6276, Abcam, 10 µg ml−1), anti-MYC (5605, CST, 1:100), anti-IRF4 (sc-6059, Santa Cruz, 0.4 µg ml−1), anti-CRBN (ab244223, Abcam, 4 µg ml−1),

(20) A multivalent adaptor mechanism drives the nuclear import of proteasomesNature CommunicationsFebruary 4, 2026Hanna L. Brunner, Robert W. Kalis, Lorenz Grundmann, Zuzana Hodáková, Zuzana Koskova, Irina Grishkovskaya, Melanie de Almeida, Matthias Hinterndorfer, Hannah Knaudt, Simon Höfflin, et al.for western blot analysis: AKIRIN2 (HPA064239, Atlas Antibodies, RRID:AB_2685222, 1:1,000), c-MYC (D84C12, no. 5605, Cell Signaling Technology, RRID:AB_1903938, 1:1,000), HRP-anti-Histone H3 (3H1, Cell Signaling (1:1,000)),

Write a Review

(1)

10/13/2020c-Myc antibody (D84C12) Rabbit mAB Federica FiorentinoGood antibody for the detection of c-Myc and very sensitive to c-Myc expressions changes
(1)

3/22/2019Great Signaling for c-Myc in T Cells Meng SunReally easy-to-use antibody for western blot if you are interested in the c-Myc expression in your cells/tissues of interest.

c-Myc (D84C12) Rabbit mAb

c-Myc (D84C12) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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c-Myc (D84C12) Rabbit mAb from Cell Signaling Technology

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