Neurocan Antibody AF5800 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemNeurocan Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF5800
NCBI Gene AliasesCspg3-rs, CSPG3, C230035B04, Tgfbit, Cspg3
HostSheep
Quantity100 ug (also 25 ug)
ApplicationsELISA Development,Immunogold Electron Microscopy,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry
ReactivityHuman,Mouse,Rat,Transgenic Mouse
TargetNeurocan
Conjugate/TagUnconjugated
IsotypeIgG
NCBI Full Gene Nameneurocan
ClonalityPolyclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ImmunogenChinese hamster ovary cell line CHO-derived recombinant mouse Neurocan, Asp23-Asp637, Accession # NP_031815
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse and rat Neurocan in direct ELISAs and Western blots.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Retrosplenial cortical reorganization during late adolescence introduces instability of contextual memory circuitsPLoS BiolJuly 17, 2026Hui Zhang, Zorica Petrovic, Elizabeth M. Wood, Ana Cicvaric, Maayan Krispil-Alon, Vladimir Jovasevic, Kendra Parker, Thomas E. Bassett, Anna Carboncino, Anita L. Guedea, et al.For immunohistochemistry, primary antibodies against aggrecan (1:1,000, ab3778, Abcam, Cambridge, UK), neurocan (1:2,000, AF5800 R&D systems), brevican (1:500, 19017-1-AP, Proteintech, Rosemont, IL, USA), phosphacan (1:500, sc-33664,

(2) Depletion of Neurocan in the Prefrontal Cortex Impairs Temporal Order Recognition, Cognitive Flexibility and Perisomatic GABAergic InnervationCell Mol NeurobiolJune 9, 2026David Baidoe-Ansah, Hector Carceller, Hadi Mirzapourdelavar, Marta Pérez-Rando, Luisa Strackeljan, Borja Garcia-Vazquez, Constanze Seidenbecher, Rahul Kaushik, Juan Nacher, Alexander DityatevPolyclonal,1:2000,Synaptic Systems,"135,304",KO validated Anti-Ncan,Sheep Polyclonal,1:100,R&D Systems,AF5800,KO validated Anti-vGLUT2,Mouse Monoclonal,1:500,Abcam,AB79157,WB bands at expected size Anti-CaMKII,Mouse

(3) 4-methylumbelliferone attenuates amyloid pathology and learning deficits in the APP/PS1 mouse modelbioRxivMay 27, 2026Matthew Amontree, James O’Leary, Pauline Wonnenberg, Mateo Nelson, Katherine Conantthe next primary antibody. Primary antibodies used included neurocan N-terminal (1:2000, R&D Systems, AF5800), neurocan C-terminal (1:2000, Invitrogen, PA5–79718), brevican (1:4000, BD Biosciences, 610894), versican

(4) Retrosplenial Cortical Reorganization During Late Adolescence Introduces Instability of Episodic Memory CircuitsResearch squareSeptember 10, 2025Radulovic J, Zhang H, Petrovic Z, Wood E, Cicvaric A, Krispil-Alon M, Jovasevic V, Parker K, Bassett T, Carboncino A, et al.For immunohistochemistry, primary antibodies against aggrecan (1:1000, ab3778, Abcam, Cambridge, UK), neurocan (1:2000, AF5800 R&D systems), brevican (1:500, 19017–1-AP, Proteintech,Rosemont, IL, USA), phosphacan (1:500, sc-33664,

(5) Aggrecan immobilizes to perineuronal nets through hyaluronan-dependent and hyaluronan-independent binding activitiesThe Journal of biological chemistryJune 1, 2025Otsuka MY, Essel LB, Sinha A, Nickerson G, Mejia SM, Edge A, Matthews RT, Bouyain S.

(6) Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic painPainMarch 17, 2025Giada Mascio, Serena Notartomaso, Roxana Paula Ginerete, Tiziana Imbriglio, Domenico Bucci, Francesca Liberatore, Alessia Ceccherelli, Sonia Castaldi, Gloria Zampini, Milena Cannella, et al.antiaggrecan (Merck, Darmstadt, Germany; #AB1031; 1:1000), sheep antineurocan (R&D System, Minneapolis; AF5800, 1:2000), goat antitenascin (R&D System, Minneapolis; AF3865, 1:1000), sheep antibrevican (R&D System,

(7) The hyaluronan-binding activity of aggrecan is important, but not essential, for its specific insertion into perineuronal netsbioRxiv : the preprint server for biologyNovember 25, 2024Otsuka MY, Essel LB, Sinha A, Nickerson G, Mejia SM, Matthews RT, Bouyain S.

(8) A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neuronsNature communicationsAugust 7, 2024Kuczynski-Noyau L, Karmann S, Alberton P, Martinez-Corral I, Nampoothiri S, Sauvé F, Lhomme T, Quarta C, Apte SS, Bouret S, et al.pharmaceutical, H-029-30; anti-aggrecan, 1/500, Millipore, AB1031; anti-neurocan, 1/500, R&D system, AF5800; anti-versican antibody anti-VC44, 1/250; anti-tenascin-R, 1/50, R&D System, AF3865; anti-phosphacan,

(9) Astrocyte-secreted neurocan controls inhibitory synapse formation and functionNeuronMay 15, 2024Irala D, Wang S, Sakers K, Nagendren L, Ulloa Severino FP, Bindu DS, Savage JT, Eroglu C.RRID:AB_1001650" NCAN C-terminal,Invitrogen,"Cat# PA5-79718, RRID: AB_2746833" NCAN N-terminal,R&D Systems,"Cat#AF5800, RRID: AB_2149717" NeuN (A60),Millipore,"Cat# MAB377, RRID:AB_2298772" NeuN,Millipore,"Cat# ABN78,

(10) Developmental patterns of extracellular matrix molecules in the embryonic and postnatal mouse hindbrainFront NeuroanatMarch 1, 2024Ildikó Wéber, Adél Dakos, Zoltán Mészár, Clara Matesz, András BirinyiBA-1000,",1:200 Biotinylated anti-sheep IgG (neurocan),Rabbit,"R&D System Minneapolis, Minnesota, United States, AF5800",1:200 "Biotinylated anti-goat IgG (tenascin-R, HAPLN1)",Rabbit,"Vector Laboratories, Burlingame, CA,

(11) Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and FunctionbioRxiv : the preprint server for biologyApril 3, 2023Irala D, Wang S, Sakers K, Nagendren L, Ulloa-Severino FP, Bindu DS, Eroglu C.

(12) Extracellular Matrix Changes in Subcellular Brain Fractions and Cerebrospinal Fluid of Alzheimer's Disease PatientsInternational journal of molecular sciencesMarch 14, 2023Höhn L, Hußler W, Richter A, Smalla KH, Birkl-Toeglhofer AM, Birkl C, Vielhaber S, Leber SL, Gundelfinger ED, Haybaeck J, et al.brevican (AF4009, R&D Systems, Minneapolis, MN, USA, 1:2000), polyclonal sheep anti-rat/mouse neurocan (AF5800, R&D Systems, Minneapolis, MN, USA, 1:1000), polyclonal goat anti-human HAPLN1 (AF2608, R&D Systems,

(13) Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular musclesScientific reportsDecember 14, 2022Ritok A, Kiss P, Zaher A, Wolf E, Ducza L, Bacskai T, Matesz C, Gaal B.,bWFAa,Anti-aggrecan,Anti-brevican,Anti-neurocan,Anti-versican,Anti-choline-acetyltransferase "Supplier, cat. no.",Sigma-Aldrich; L1516,Merck Millipore; AB1031,R&D Systems; AF4009,R&D Systems; AF5800,Biorbyt; orb259630,Merck Millipore; AB144P "Species of origin, type",Lectin isolated from Wisteria floribunda

(14) Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse ModelBiomoleculesMarch 26, 2022Schmidt S, Holzer M, Arendt T, Sonntag M, Morawski M.of neurocan in the Mo5 of TauP301L-acan mice. (A–D) Immunohistochemical analysis of neurocan (NCAN, AF5800 (R&D Systems)) in the motor trigeminal nucleus (Mo5) of 3 TauP301LHET-acanWT (A,B) and 3 TauP301LHET-acanHET

(15) Brevican and Neurocan Cleavage Products in the Cerebrospinal Fluid - Differential Occurrence in ALS, Epilepsy and Small Vessel DiseaseFrontiers in cellular neuroscienceJanuary 1, 2022Hußler W, Höhn L, Stolz C, Vielhaber S, Garz C, Schmitt FC, Gundelfinger ED, Schreiber S, Seidenbecher CI.(AF4009, R&D Systems, Minneapolis, United States, 1:1000), polyclonal sheep anti-rat/mouse neurocan (AF5800, R&D Systems, Minneapolis, United States, 1:1000), and the antibodies from the ELISA kits (see above). To

(16) Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstemBrain and behaviorAugust 1, 2019Heusinger J, Hildebrandt H, Illing RB.AB_2250826",–/1:40/1:20 Neurocan,"Mouse/rat neurocan, full‐length form and proteolytic fragments","R&D Systems, sheep polyclonal, AF5800, AB_2149717","1:1,000/1:500/1:500" vGluT1,Synthetic peptide from rat vesicular glutamate transporter

(17) Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform corticesIBRO reportsJune 1, 2019Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, Okamoto M, Ishihara T.anti-tenascin-R (AF3865, R&D Systems; 1:200), rabbit anti-aggrecan (AB1031, MERCK; 1:200), sheep anti-neurocan (AF5800, R&D Systems, 1:25), sheep anti-brevican (AF4009, R&D Systems, 1:200), mouse anti-aggrecan (Cat-315;

(18) Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in NeuropathiesCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyJanuary 1, 2019Fontanil T, Mohamedi Y, Moncada-Pazos A, Cobo T, Vega JA, Cobo JL, García-Suárez O, Cobo J, Obaya ÁJ, Cal S.24934-1-AP). Neurocan was detected using a mouse/rat anti-neurocan antibody from R&D Systems (Ref. AF5800). When indicated, the loading control was examined using an anti-α-actin antibody from Sigma-Aldrich

(19) Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal netsBMC biologySeptember 26, 2018Sonntag M, Blosa M, Schmidt S, Reimann K, Blum K, Eckrich T, Seeger G, Hecker D, Schick B, Arendt T, et al.

(20) BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury ResponseThe Journal of neuroscience : the official journal of the Society for NeuroscienceApril 11, 2018Chen J, Van Gulden S, McGuire TL, Fleming AC, Oka C, Kessler JA, Peng CY.

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Neurocan Antibody

Neurocan Antibody

Neurocan Antibody

Neurocan Antibody

Neurocan Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Neurocan Antibody from R&D Systems, a Bio-Techne Brand

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