Fig 1: Defective Development of B, T, and NK Cells in Various Genetically Mutant Rats(A) NK cells, B cells, and T cells are abolished in SG (Prdkc−/−Il2rγ−/−) and NSGL (hSIRPα+Prdkc−/−Il2rγ−/−) rats. In addition, NSGL rats co-expressed human SIRPα and rat SIRPα on the peripheral blood leukocytes. The genotypes are indicated on the top and cell types on the left. The percentage of the gated cells within the CD45+ leukocytes is indicated. PBMC, peripheral blood mononuclear cells.(B) Statistical analysis of the percentage of NK cells, B cells, and T cells in the CD45+ leukocytes in the peripheral blood of WT (N = 10), SG (N = 14), and NSGL (N = 18) rats. Mean value ± SD are presented. p values are indicated.