Fig 1: GPR44 expression colocalized with beta cells in human islet. The formalin-fixed, paraffin-embedded tissue sections of adult human pancreases were examined via double and immunofluorescence staining for the GPR44 antibody (red), together with islet major hormones, insulin (green), glucagon (green), and somatostatin (green). DNA was stained blue with DAPI. Data were verified in human pancreases from three to four independently deceased donors.
Fig 2: GPR44 expression in human 1.1 B4 cell line via Western blot analysis.
Fig 3: Biodistribution of NOD/SCID mice with transplanted human islets in kidney capsules at 30 min after the administration of the radiolabel. The results indicate the high specific binding to the human islet, in which GPR44 has high expression.
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