Fig 1: Representative histology of paired tumour and benign-appearing prostatic tissue samples for 21 biomarkers.All prostatic tissue slices were processed, stained using BOND-MAX Autostainer, and reviewed to assess the staining intensity of each biomarker in benign (b) and tumour (t) tissue. The staining of AGR2, AMACR, ANPEP, AR, CD10, ERG, GDF15, KHDRBS3, MSMB, PCLAF, NAALADL2, NKX3.1, PSA, PSMA, PTEN, SIK2, TBL1XR1, TP63, TRMT12, VPS13A and VPS28 are shown in brown and nuclei shown in blue. Full details of all staining conditions can be found in Table 1. Each marker was scored using the h-score method. The white and black arrowheads in some examples refer to benign and tumour tissues in a malignant core.