Fig 1: Expression levels of the cell cycle regulators in psoriasis. (A) Relative mRNA expression of cop1 (left) and mdm2 (right) genes at three time points. (B) Daily changes of mRNA expression of cop1 (left) and mdm2 (right) genes. Significant differences assessed by two-way ANOVA followed by Turkey’s post hoc test between the time points: * p < 0.05; ** p < 0.005; *** p <0.0005. Data are presented as the means ± SEM. (C) Representative DAB-stained skin sections at 06:00.