Fig 2: SDPR inhibits LUAD cells proliferation and migration in vitro. A. The mRNA expression levels of SDPR in LUAD cell lines determined by RT-qPCR. B. The protein expression levels of SDPR in LUAD cell lines determined by western blot. C. The expression of SDPR in SDPR ex-pressing plasmid transfected H1299 and PC-9 cells determined by western blot. D-F. MTT (D), Colony formation (E) and EdU analysis (F) in SDPR-overexpressed H1299 and PC-9 cells. G-H. Transwell (G) and Scratch analysis (H) of SDPR-overexpressed H1299 and PC-9 cells, as well as control cells. *P <0.05, **P <0.01, ***P < 0.001.

Fig 3: SDPR induce cell apoptosis and cell cycle arrest at S phase. A. The cell apoptosis analysis of SDPR-overexpressed H1299, PC-9 cells and control cells determined by flow cytometry analysis. B. The cell cycle distribution of SDPR-overexpressed H1299, PC-9 cells and control cells deter-mined by flow cytometry analysis. C. The expression of cell cycle related proteins determined by western blot. D-E. The cell cycle synchronization analysis of SDPR-overexpressed PC-9 and control cells determined by flow cytometry analysis. **P <0.01, ***P < 0.001.