m6A Antibody 202 003 from Synaptic Systems GmbH

Product Specs
Itemm6A Antibody
CompanySynaptic Systems GmbH
Price $480.00Supplier Page View Company Product Page
Catalog Number202 003
Hostrabbit
Quantity50 µg
Targetm6A
Reactivityhuman, rat, mouse, eukaryotes, prokaryotes
ApplicationsDot blot, IP, MeRIP
Clonalitypolyclonal
Purityaffinity purified
ImmunogenN6-methyladenosine fused to BSA
Antibody TypePrimary antibody
Formatlyophilized

Questions and Answers

Can this m6A antibody be used for studying the role of m6A modifications in viral infections?

Yes, the m6A antibody has been utilized in studies investigating the role of m6A modifications in viral infections. For instance, it was employed in research demonstrating that m6A-modified viral transcripts are recognized and destabilized by the YTHDF1 protein, which leads to the suppression of Epstein-Barr virus replication ().

Is this antibody effective for immunoprecipitation applications?

The m6A antibody has been shown to work effectively in immunoprecipitation applications. In one study, it was used to pull down m6A-modified RNA, allowing for subsequent analysis of RNA stability and interactions with RNA-binding proteins ().

What types of samples can this antibody be applied to in research?

This antibody has been successfully applied to various sample types, including human tissues and cultured cells. For example, it has been used in studies involving pancreatic ductal adenocarcinoma tissues to assess m6A levels and their implications in tumor biology ().

How does this antibody contribute to understanding m6A's role in gene regulation?

The m6A antibody facilitates the investigation of m6A's role in gene regulation by enabling researchers to analyze m6A modifications on specific mRNAs. For instance, it has been used to study how m6A methylation affects the stability and expression of genes involved in macrophage activation during bacterial infections ().

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) CD133-Guided RNA Nanoparticle Delivery of FTO siRNA Impairs Leukemia Resistance to Tyrosine Kinase Inhibitor TherapyRNA NanoMedApril 20, 2026Department of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive,Cleveland, OH 44109, USA, Huiqin Bian, Changli Zhou, Hiroaki Koyama, Wen Gao, Sicheng Bian, Tao Cheng, Xiaonan Han, Department of Medicine, The MetroHealth System, Case Western Reserve University, 2500 Metro Health Drive,Cleveland, OH 44109, USA, William Tse, et al.fragments using sonication. The fragmented RNAs were incubated for 12 hours at 4 °C with 5 μl anti-m6A (#202003, Synaptic System) in IPP buffer. The mixture was then immunoprecipitated by incubation with Dynabeads™

(2) Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparumeLifeApril 15, 2026Todd Lenz, Madle Sirel, Hannes Hoppe, Sulman Shafeeq, Karine G Le Roch, Ulf RibackeNF54CSAh only, 3 μg of polyclonal rabbit anti-5mhC (#39069, Active Motif) and polyclonal rabbit anti-6mA (#202003, Synaptic Systems) was used respectively. Immune complexes were collected using 20 μL of protein G magnetic

(3) Screening of M6a methylated genes associated with preovulatory follicle development in Bashang long-tailed chickenPoult SciApril 1, 2026Xiaoyan Duan, Jiale Xie, Shaoru Yin, Liyong Zhang, Yu Liufor 7 min. The cleaved RNA fragments were incubated for 2 h at 4°C with m6A-specific antibody (No. 202003, Synaptic Systems, Germany) in IP buffer (50 mM Tris-HCl, 750 mM NaCl, and 0.5% Igepal CA-630). The

(4) ALKBH5 facilitates Srgn stability via m6A demethylation to disrupt blood-testis barrier integrity in the high-fat diet miceCellular and Molecular Life SciencesMarch 30, 2026Tian Du, Liangyu Yao, Wenhua Wang, Zhou Li, Jie Dong, Zheng Zhou, Chengyu Shi, Xie Ge, Rujun Ma, Li Chen, et al.with BSA. After washing twice with PBS, cells were incubated with primary antibodies of m6A (1:200, 202003, Synaptic Systems) at 4 °C overnight. Finally, cells were incubated with secondary antibody and the

(5) Dynamic regulation of mRNA acetylation at synapses by spatial memory in mouse hippocampuseLifeMarch 23, 2026Hai-Qian Zhou, Zhen Zhu, Jia-Wei Zhang, Wei-Peng Lin, Hao-JY Jin, Yang-Yang Ding, Shuai Liu, Dong-Min Yinwith 5% nonfat milk for 2 hr at RT and incubated with the rabbit anti-m6A (1:2000, Synaptic System, #202003) or anti-ac4C antibody (1:500, Abcam, ab252215) at 4°C overnight. After washing with 0.05% PBST for

(6) Integrative Multi-Analysis Identifies METTL3-Regulated FGF19 and H6PD as Candidate Targets in Diabetic Cognitive ImpairmentBiomoleculesMarch 20, 2026Jun Fu, Huarui Wang, Junjie Yan, Weiyuan Chen, Ruguang Wang, Hongchang Gao, Chen Li(Affinity BiosciencesCincinnati, OH, USA) (1:1000), anti-m6A (Synaptic Systems, Göttingen, Germany, 202003) (for Dot blot:1:1000, for IHC: 1:500), anti-METTL3 (15073-1-AP, Proteintech, Rosemont, Illinois, USA)

(7) m6A reader Ythdf proteins control retrotransposon B2 repeat expression and safeguard early embryo developmentThe EMBO JournalMarch 11, 2026Ruibao Su, Di Gao, Zongchang Du, Tie-Gang Meng, Chao Li, Lei-Ning Chen, Xiaoting Lin, Changchang Cao, Li-Hua Fan, Yanbin Dong, et al.,Thermo Scientific,A11029 AF647-labeled Goat Anti-Mouse IgG (H + L),Beyotime,A0473 Anti-m6A,Synaptic Systems,202003 Oligonucleotides and other sequence-based reagents,Oligonucleotides and other sequence-based reagents,Oligonucleotides

(8) DNA polymorphisms and N6-methyladenosine RNA methylation influencing microRNA expression and regulatory activity in plantsBMC Plant BiologyMarch 6, 2026Zedi Feng, Jia Yao, Zhifang Jiang, Xiaomei Wu, Jiacen Wang, Wenyuan Wu, Chaogang Shao, Xiaoxia Ma, Yijun Mengfor 7 min. The fragmented RNAs were incubated with the m6A-specific antibody (Synaptic Systems, cat.202003, Germany) in IP buffer (50 mM Tris-HCl, 750 mM NaCl and 0.5% Igepal CA-630) at 4℃ for 2 h. The immunoprecipitated

(9) Emerging role of N6-methyladenosine (m6A) epitranscriptomic changes in adult anxiety after adolescent alcohol exposureNeuropharmacologyMarch 1, 2026Emir Malovic, Jamuna Tandukar, Huaibo Zhang, Lalith K. Venkareddy, Ruixuan Gao, Subhash C. PandeyPrimary antibodies [anti-METTL3 (1:500) from Abcam (ab195352); anti-M6A (1:500) from Synaptic Systems (202003)] were placed into a diluted blocking buffer (containing 5% normal donkey serum, 0.5% BSA, and 0.125%

(10) Lipid deposition promotes YTHDF3-mediated m6A modification of PPARα to facilitate liver metastasis of colorectal cancerProtein & CellMarch 1, 2026Wen Ni, Yuanyuan Xu, Mengrou Zhang, Yuqing Yuqing, Piao Huang, Zhun Li, Qi Wu, Hui Mo, Yibiao Ye, Yuhui Li, et al.the cleaved RNA fragments were subjected to incubated for 2h at 4°C with m6A-specific antibody (No. 202003, Synaptic Systems, Germany) in IP buffer. The mixture was then incubated with protein-A beads and eluted

(11) Magnesium ions facilitate osteogenic differentiation and intervertebral fusion via m6A methylation of RhoA mRNAJournal of Orthopaedic TranslationMarch 1, 2026Haocheng Xu, Linli Li, Fan Zhang, Minghao Shao, Chenyan Li, Yitong Xue, Dachuan Li, Zhidi Lin, Zhaoyang Gong, Jiongdong Wu, et al.temperature for 2 h. Subsequently, the N+ nylon membranes were incubated overnight with an anti-m6A antibody (202003, Synaptic Systems, 1:1000). Afterward, a rabbit secondary antibody (111-035-003, Jackson ImmunoResearch,

(12) Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m 6 A‐Dependent hnRNPA2B1/COX‐2 AxisAdvanced ScienceMarch 1, 2026Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, et al.fragmentation buffer. Fragmented mRNA was immunoprecipitated with anti‐m6A antibody (Synaptic Systems, Cat# 202003, RRID: AB_2279214), and 1/10 of the fragmented mRNA was kept as input. 5.20 RNA Stability Assays Cells

(13) SERPINA4 facilitates colorectal cancer progression through m⁶A-dependent stabilizationJournal of Translational MedicineFebruary 28, 2026Xiaoyu Zhang, Yutong Liu, Qianyi Tu, Dandan Zhang, Jiaqi Deng, Jingjiao Zhou, Hui Lv, Jun Zhou, Fengwu Qiu, Yang DengKit (Millipore, #17-10499). Fragmented RNA was incubated with anti-m6A antibody (Synaptic Systems, #202 003) bound to magnetic beads. The enriched RNA was then purified and quantified by RT-qPCR to evaluate m6A

(14) Epididymal macrophage senescence contributes to sperm motility decrease upon environmental stressScience AdvancesFebruary 27, 2026Xin-Run Wang, Hao Li, Yong-Wei Xiong, Zhi Yuan, Xin-Yi Cheng, Yi-Fan Hu, Xiao-Jin He, Long-Long Fan, Ye-Xin Luo, Jian Sun, et al.of the purified mRNA was reserved. Next, 2 μg of an anti-m6A polyclonal antibody (Synaptic System, 202003) was added to the reaction system, and the mixture was incubated at 4°C for 2 hours. Then, Dynabeads

(15) Methyltransferase like 3 promotes thyroid folliculogenesis via coordinating cell differentiation and polarizationJournal of Translational Internal MedicineFebruary 23, 2026Ruoyu Jiang, Qibo Zhu, Zhenlei Zhang, Xiao He, Yifan Liu, Ronglin Kan, Xianghui He, Haixia GuanSubsequently, 30 μL of A/G magnetic beads (#P2108, Beyotime, China) were mixed with 1 μg of anti-m6A antibody (#202003, Synaptic Systems, Germany) or normal rabbit IgG (#2729, Cell Signaling Technology, USA) and incubated

(16) N6-methyladenosine (m6A) modification of TXNIP in 3′UTR instigates abdominal aorta aneurysm in miceiScienceFebruary 20, 2026Fransky Hantelys, Wenfeng Yin, Ming Hui Zouprecipitation. The fragmented mRNA (5 μg) was incubated with 2 μg of anti-m6A antibody (Synaptic Systems, 202003) or mouse IgG (Beyotime, A7028) in 600 μL of RIP buffer (150 mM NaCl, 0.1% Igepal CA-630, 10 mM Tris-HCl,

(17) N6-methyladenosine within transmissible gastroenteritis virus genomic RNA inhibits its replication via efficient recognition by RNA sensor RIG-IJournal of VirologyFebruary 17, 2026Jianing Chen, Shengyu Lin, Qianzi Liu, Mengling Gao, Zemei Wang, Jiao Tang, Yaru Cui, Chen Tan, Guangliang LiuAbbkine), anti-GAPDH mAb (ABL1020, Abbkine), anti-β-actin mAb (ABL1010, Abbkine), rabbit anti-m6A pAb (202 003-50, Synaptic Systems), rabbit anti-FTO mAb (ab126605, Abcam), rabbit anti-METTL3 mAb (ab195352, Abcam),

(18) Comprehensive analysis and validation of m6A-G4 colocalization and its regulatory role in Marek’s disease virus infectionBMC Veterinary ResearchFebruary 13, 2026Lulu Yao, Yunzhe Kang, Xuyang Zhao, Lucai Wang, Lijie Lv, Wenhui Zhu, Xiuwen Yang, Guoqing Zhuang, Aijun Sun(New England Biolabs, S1550S, USA). RNA was incubated with anti-m6A polyclonal antibodies (Synaptic Systems, 202–003, Germany) in IP buffer at 4 °C for 2 h followed by washing three times. The conjugate was eluted and

(19) The dynamic landscape and conserved regulation of the m6Am and m6A methylomes during the human and mouse oocyte-to-embryo transitionNucleic Acids ResFebruary 10, 2026Ruibao Su, Zongchang Du, Sen Li, Hanyan Liu, Di Gao, Shaoquan Zhan, Chao Li, Tie-Gang Meng, Lei-Ning Chen, Li-Hua Fan, et al.incubated at 37°C for 3 min with gentle mixing. Then, 0.5–1 μg of anti-m6A antibody (Synaptic Systems, 202003) was added to the lysate and rotated for 2 h at 4°C. The solution was cross-linked twice with 0.4 J

(20) METTL3 promotes pancreatic cancer immune escape by m6A modification of lncRNA AFAP1-AS1 to enhance EGR2 stabilityEuropean Journal of Medical ResearchFebruary 4, 2026DaoJun Zhu, RongXi Shen, Min Licontrol. The remaining fragmented RNA was incubated with magnetic beads pre-coated with anti-m6A (Cat# 202,003, Synaptic Systems, Goettingen, Germany) or negative control IgG at 4 °C overnight. The m6A-modified

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4/15/2016Review of Synaptic Systems m6A Antibody for IP and Sequencing Simen ZhaoSynaptic systems m6A antibody is one of the best antibodies to carry out m6A-related studies.

m6A Antibody

m6A Antibody

m6A Antibody from Synaptic Systems GmbH

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Synaptic Systems GmbH

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m6A Antibody from Synaptic Systems GmbH

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