Fig 1: Targeting specificity depends on specific SNARE combinations. a Liposomes containing only the three early endosomal Q-SNAREs Stx13, Stx6, and vti1a (3-EE-SNARE PL) show the same targeting specificity as liposomes containing the complete set (4-EE-SNARE PL). All values were normalized to the degree of co-localization observed in control injections using protein-free liposomes. b, c Targeting specificity of injected liposomes containing either various combinations of two early endosomal SNAREs (b) or individual SNAREs (c). For comparison, the results obtained for liposomes containing the complete set of early endosomes (4-EE-SNARE PL) are shown. Note that no specific targeting was observed to vesicles containing Golgin97 or PDI (not shown). *P < 0.05, **P < 0.01, ***P < 0.001, all determined by unpaired t-test
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