Fig 1: (A) TRIM27 immunostaining in the retina ONL of wild-type and Ataxin-7266Q/+ mouse retina at 5, 8 and 10 weeks of age, as indicated. The knock-in mice have increased expression of TRIM27, which is particularly evident at the later disease point. (B) TRIM23 immunostaining in wild-type and Ataxin-7266Q/+ mouse retina at 5, 8 and 10 weeks of age, as indicated. The staining is more pronounced in the WT mice as they age compared with knock-in mice. (C) Calbindin (green) and TRIM23 (red) are shown for wild-type and knock-in samples at 10 weeks.