Fig 1: Downregulation of p38a in myeloid cells reduces inflammation in the tumor microenvironment ARepresentative images of intestinal macrophages isolated from the colonic lamina propria and stained for F4/80 and CD115. Scale bars, 10 µm (F4/80) and 100 µm (CD115).BRepresentative immunoblots of p38a in lysates from peritoneal macrophages.CAverage tumor size (n = 11).DNumber of tumors > 4 and >6 mm in AOM/DSS-treated mice (n = 11).E, FRepresentative sections from normal colon epithelia and colon tumors stained for Ki67 (n = 6) (E) and phospho-STAT3 (n = 3) (F). Quantifications are shown in the histogram. Scale bars, 100 µm.Data information: Statistical analysis was performed by using Mann–Whitney test for the comparison of two groups or ANOVA using Bonferroni post hoc correction for multiple groups. Data are expressed as the average ± SD.